Title
Transgalactooligosaccharides stimulate calcium absorption in postmenopausal women
Author
van den Heuvel, E.G.H.M.
Schoterman, M.H.C.
Muijs, T.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2000
Abstract
The aim of this study was to investigate whether a product rich in transgalactooligosaccharides (TOS, Elix'or) stimulates true Ca absorption in postmenopausal women. The study was a double-blind, randomized crossover study, consisting of two 9-d treatment periods separated by a 19-d washout period. During the treatment periods, 12 subjects drank 200 mL yogurt drink twice (at breakfast and lunch) containing either TOS (20 g/d) or the reference substance, sucrose. On d 8 of each treatment period, 44Ca and 48Ca were administered orally and intravenously, respectively. Before and during the 36 h after isotope administration, urine was collected and the ratios of isotopes present were measured by inductively coupled plasma mass spectrometry (ICP-MS). From the isotope enrichments, true calcium absorption was calculated. TOS increased true calcium absorption 16%, from (mean ± SD) 20.6 ± 7.0% during the reference treatment to 23.9 ± 6.9% during the TOS treatment (P = 0.04, one-sided). In conclusion, in this study in postmenopausal women, greater Ca absorption was observed after consumption of a product rich in TOS (Elix'or) compared with the reference treatment. This increase in Ca absorption was likely due solely to TOS. The increased Ca absorption was not accompanied by increased urinary Ca excretion, meaning that TOS also may indirectly increase the uptake of Ca by bones and/or inhibit bone resorption.
Subject
Nutrition
Calcium absorption
Postmenopausal women
Stable isotopes
Transgalactooligosaccharides
Calcium
Oligosaccharide
Stable isotope
Bone metabolism
Calcium absorption
Calcium excretion
Clinical trial
Controlled clinical trial
Controlled study
Crossover procedure
Dietary intake
Double blind procedure
Female
Human
Human experiment
Isotope labeling
Normal human
Osteolysis
Postmenopause
Randomized controlled trial
Urinalysis
Administration, Oral
Aged
Calcium
Cross-Over Studies
Double-Blind Method
Female
Humans
Injections, Intravenous
Intestinal Absorption
Middle Aged
Oligosaccharides
Osteoporosis, Postmenopausal
Postmenopause
Radioactive Tracers
Spectrophotometry
Yogurt
Toscana virus
To reference this document use:
http://resolver.tudelft.nl/uuid:6ee981fb-b96b-4217-aebe-63ec26737924
TNO identifier
43303
ISSN
0022-3166
Source
Journal of Nutrition, 130 (12), 2938-2942
Bibliographical note
Correspondence Address: Van den Heuvel, E.G.H.M.; TNO Nutrition and Food Research, Nutritional Physiology, Utrechtseweg 48, Zeist, Netherlands Chemicals/CAS: Calcium, 7440-70-2; Oligosaccharides; Radioactive Tracers
Document type
article