Print Email Facebook Twitter Transgalactooligosaccharides stimulate calcium absorption in postmenopausal women Title Transgalactooligosaccharides stimulate calcium absorption in postmenopausal women Author van den Heuvel, E.G.H.M. Schoterman, M.H.C. Muijs, T. Centraal Instituut voor Voedingsonderzoek TNO Publication year 2000 Abstract The aim of this study was to investigate whether a product rich in transgalactooligosaccharides (TOS, Elix'or) stimulates true Ca absorption in postmenopausal women. The study was a double-blind, randomized crossover study, consisting of two 9-d treatment periods separated by a 19-d washout period. During the treatment periods, 12 subjects drank 200 mL yogurt drink twice (at breakfast and lunch) containing either TOS (20 g/d) or the reference substance, sucrose. On d 8 of each treatment period, 44Ca and 48Ca were administered orally and intravenously, respectively. Before and during the 36 h after isotope administration, urine was collected and the ratios of isotopes present were measured by inductively coupled plasma mass spectrometry (ICP-MS). From the isotope enrichments, true calcium absorption was calculated. TOS increased true calcium absorption 16%, from (mean ± SD) 20.6 ± 7.0% during the reference treatment to 23.9 ± 6.9% during the TOS treatment (P = 0.04, one-sided). In conclusion, in this study in postmenopausal women, greater Ca absorption was observed after consumption of a product rich in TOS (Elix'or) compared with the reference treatment. This increase in Ca absorption was likely due solely to TOS. The increased Ca absorption was not accompanied by increased urinary Ca excretion, meaning that TOS also may indirectly increase the uptake of Ca by bones and/or inhibit bone resorption. Subject NutritionCalcium absorptionPostmenopausal womenStable isotopesTransgalactooligosaccharidesCalciumOligosaccharideStable isotopeBone metabolismCalcium absorptionCalcium excretionClinical trialControlled clinical trialControlled studyCrossover procedureDietary intakeDouble blind procedureFemaleHumanHuman experimentIsotope labelingNormal humanOsteolysisPostmenopauseRandomized controlled trialUrinalysisAdministration, OralAgedCalciumCross-Over StudiesDouble-Blind MethodFemaleHumansInjections, IntravenousIntestinal AbsorptionMiddle AgedOligosaccharidesOsteoporosis, PostmenopausalPostmenopauseRadioactive TracersSpectrophotometryYogurtToscana virus To reference this document use: http://resolver.tudelft.nl/uuid:6ee981fb-b96b-4217-aebe-63ec26737924 TNO identifier 43303 ISSN 0022-3166 Source Journal of Nutrition, 130 (12), 2938-2942 Bibliographical note Correspondence Address: Van den Heuvel, E.G.H.M.; TNO Nutrition and Food Research, Nutritional Physiology, Utrechtseweg 48, Zeist, Netherlands Chemicals/CAS: Calcium, 7440-70-2; Oligosaccharides; Radioactive Tracers Document type article Files To receive the publication files, please send an e-mail request to TNO Library.