Print Email Facebook Twitter Toxicologic studies of iocetamic acid in rats and dogs Title Toxicologic studies of iocetamic acid in rats and dogs Author Centraal Instituut voor Voedingsonderzoek TNO Janbroers, J.M. Sanders, J.C. Til, H.P. Feron, V.J. de Groot, A.P., Publication year 1969 Abstract A new oral cholecystographic medium called iocetamicacid was submitted to a toxicologic study in rats and dogs. Dosages, which were equivalent to 200 and 1000 mg of the compound per kilogram of body weight per day and were 5 times and 25 times the human routine dose, were administered daily for 3 weeks in order to establish whether the substance exerted an untoward influence on vital organs. In the male rats the thyroid was activated by both doses, but no thyroid activation was demonstrable in dogs. There were no indications of damage of the cells of the liver or kidney. The study showed that iocetamic acid had no special affinity for the kidneys. With the exception of the increased thyroid activity in male rats, no changes were found which could be ascribed to the administration of iocetamic acid. © 1969. Chemicals/CAS: iodine, 7553-56-2; Butyrates; Contrast Media; Iodine, 7553-56-2 Subject butyric acid derivativedrug effectAnimalButyratesContrast MediaDogsFemaleIodineKidneyKidney Function TestsLiverLiver Function TestsMaleRatsThyroid Gland To reference this document use: http://resolver.tudelft.nl/uuid:6e2b5c63-5c79-4c53-a997-48b5ce6a3bd0 TNO identifier 227110 ISSN 0041-008X Source Toxicology and Applied Pharmacology, 14 (14), 242-248 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.