Title
Factors determining cell killing by chemotherapeutic agents In Vivo-II: Melphalan, chlorambucil and nitrogen mustard
Author
van Putten, L.M.
Lelieveld, P.
Radiobiologisch Instituut TNO
Publication year
1971
Abstract
The sensitivity of resting spleen colony-forming cells in normal mouse bone marrow and of rapidly-proliferating spleen colony-forming cells in repopulating mouse spleen to a number of bis-chloro-aethyl-amines was determined. The rapidly-growing cells were more sensitive to each of the agents than the resting cells. The equal degree of sensitization to these agents by an increased rate of proliferation of the cells points to a common mechanism for all agents of this type. It is suggested that repair of damaged DNA, by excision of alkylated bases or oligonucleotides before the damage becomes irreversible during the next DNA synthetic period, is the most likely explanation of the uniform difference in sensitivity caused by the modified rate of cell proliferation. © 1971. Chemicals/CAS: chlorambucil, 305-03-3; chlormethine, 51-75-2, 55-86-7, 82905-71-3; cyclophosphamide, 50-18-0; DNA, 9007-49-2; melphalan, 148-82-3; Chlorambucil, 305-03-3; Cyclophosphamide, 50-18-0; DNA, 9007-49-2; Mechlorethamine, 51-75-2; Melphalan, 148-82-3
Subject
Drug effect
female
hematopoietic stem cell
metabolism
Animal
Bone Marrow
Bone Marrow Cells
Cell Survival
Chlorambucil
Cyclophosphamide
DNA
Female
Hematopoietic Stem Cells
Male
Mechlorethamine
Melphalan
Mice
Spleen
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TNO identifier
227235
ISSN
0014-2964
Source
European Journal of Cancer, 7 (1), 11-16
Document type
article