Print Email Facebook Twitter Increase of fungitoxicity of mercuric chloride by methionine, ethionine and s methylcysteine Title Increase of fungitoxicity of mercuric chloride by methionine, ethionine and s methylcysteine Author Organisch Chemisch Instituut TNO Vonk, J.W. Kaars Sijpesteijn, A. Publication year 1974 Abstract The fungitoxicity of mercuric chloride to Aspergillus niger was increased in the presence of D-, L-, DL-methionine, DL-ethionine, DL-S-methylcysteine or sodium methylmercaptide. The same effect was observed with methionine for two other fungi investigated: Cladosporium cucumerinum and Scopulariopsis brevicaulis. It is suggested that this effect can be ascribed to the formation of CH3SHg+ or (CH3S)2Hg, or the corresponding ethyl compounds. CH3SHgCl and (CH3S)2Hg were synthetically prepared and proved indeed far more fungitoxic than HgCl2. The hypothesis was further substantiated by the observation that A. niger rapidly converts DL-methionine into CH3SH, which undoubtedly reacts with Hg2+ to give the above mentioned methylthiomercury compounds. Chemicals/CAS: cystathionine, 56-88-2; cysteine, 4371-52-2, 52-89-1, 52-90-4; dimethyl sulfide, 75-18-3; ethionine, 13073-35-3, 67-21-0; homocysteine, 454-28-4, 6027-13-0; mercurous chloride, 10112-91-1, 7546-30-7; methionine sulfone, 1118-85-0, 7314-32-1; methionine sulfoxide, 454-41-1; methionine, 59-51-8, 63-68-3, 7005-18-7; s methylcysteine, 7728-98-5; Antifungal Agents; Cysteine, 52-90-4; Ethionine, 13073-35-3; Mercury, 7439-97-6; Methionine, 63-68-3; Sulfhydryl Compounds Subject Butyric acid derivativeCystathionineCysteineDimethyl sulfideEthionineHomocysteineMercurous chlorideMethionineMethionine sulfonemethionine sulfoxideS methylcysteine3 methylcytidineAspergillus nigerCladosporiumCladosporium cucumerinumDrug potentiationEnvironmental healthFungitoxicityMethylmercury sulfideMicroorganismPropylamine derivativeScopulariopsisScopulariopsis brevicaulisTheoretical studyAntifungal AgentsAspergillusBacillus subtilisCysteineDrug SynergismEthionineKlebsiellaMercuryMethionineMethylationMitosporic FungiPenicilliumSulfhydryl Compounds To reference this document use: http://resolver.tudelft.nl/uuid:6ba183c2-bdb1-4799-a822-9b4423ed3086 TNO identifier 227680 ISSN 0003-6072 Source Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology, 40 (40), 393-400 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.