Title
Toxicologic profile of acrylonitrile
Author
Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding
Woutersen, R.A.
Publication year
1998
Abstract
Acrylonitrile is a monomer used extensively as a raw material in the manufacturing of acrylic fibers, plastics, synthetic rubbers, and acrylamide. It has been classified as a probable human carcinogen according to the results of numerous chronic rat bioassays. The present report summarizes the toxicity data on acrylonitrile and reviews available data concerning the mechanism (genetic versus epigenetic) by which acrylonitrile is carcinogenic in rats. From the evaluation of the relevant toxicity data, it can be concluded that acrylonitrile is indeed carcinogenic to rats after either oral or inhalational exposure. However, information on other mammalian species is lacking, and, moreover, the exact mechanism of the carcinogenic process is unclear. Therefore, it is recommended to conduct an additional long-term inhalation carcinogenicity study with acrylonitrile in mice, as well as studies into the mechanism by which acrylonitrile induces (brain) tumors in rats (genetic versus epigenetic). Chemicals/CAS: Acrylonitrile, 107-13-1; Carcinogens; Mutagens
Subject
Carcinogenicity
Mechanism
Oral
Animal experiment
Animal model
Brain tumor
Conference paper
Genetics
Inhalation
Inhalational drug administration
Mammal
Mouse
Mouth
Nonhuman
Oral drug administration
Toxicology
Acrylonitrile
Administration, Oral
Animals
Carcinogens
Disease Models, Animal
Dogs
Guinea Pigs
Humans
Inhalation Exposure
Lethal Dose 50
Mice
Mutagens
Rabbits
Rats
Risk Assessment
Animalia
Mammalia
To reference this document use:
http://resolver.tudelft.nl/uuid:6b4a1e65-b06a-49b7-8e70-d4d5ee6f0011
TNO identifier
55582
Source
Scandinavian Journal of Work Environmental & Health, 24 (24), 5-9
Document type
article