Print Email Facebook Twitter The effects of physical activity and fitness in adolescence on cognition in adulthood and the role of insulin-like growth factor I Title The effects of physical activity and fitness in adolescence on cognition in adulthood and the role of insulin-like growth factor I Author Ferro, D.A. Deijen, J.B. Koppes, L.L. van Mechelen, W. Twisk, J.W. Drent, M.L. Publication year 2016 Abstract Background: Physical activity and fitness in adolescence may improve cognition in adulthood by increasing insulin-like growth factor I (IGF-I). Methods: As part of the Amsterdam Growth and Health Longitudinal Study, following subjects from age 13 to 42 years, physical activity and fitness of 303 subjects were assessed annually between the ages 13 to 16. At mean age 36, physical activity, fitness and IGF-I were measured. At mean age 42, IGF-I and cognitive factors (ie, executive functioning and visual-spatial memory) were measured. The linear regression of physical activity and fitness in adolescence and IGF-I in adulthood on cognitive scores in adulthood was investigated. Results: A significant association was found in males between physical activity in adolescence and executive function in adulthood (Spatial Working Memory Between Errors: Î² = -.18, B = -.13, 95% CI = -.259 to -.010; Spatial Working Memory Strategy: Î² = -.20, B = -.08, 95% CI = -.147 to -.014). No association between physical activity or fitness in adolescence and cognitive function in adulthood was found in females, nor any intermediate role for IGF-I in either sex. Conclusions: The results suggest a stimulating effect of adolescent physical activity in males on executive functions in adulthood, emphasizing the importance of an active lifestyle among adolescent males. Â© 2016 Human Kinetics, Inc. Subject LifeWHC - Work, Health and CareELSS - Earth, Life and Social SciencesWork and EmploymentWorkplaceHealthy LivingCognitive agingExecutive functionIGF-ILifestyleMemory To reference this document use: http://resolver.tudelft.nl/uuid:6afcc260-97d1-4930-a160-07a8f7c45e6b DOI https://doi.org/10.1123/jpah.2014-0594 TNO identifier 537433 ISSN 1543-3080 Source Journal of Physical Activity and Health, 13 (4), 392-402 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.