Print Email Facebook Twitter ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels Title ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels Author Gaubius Instituut TNO Preventie en Gezondheid Neale, M.C. de Knijff, P. Havekes, L.M. Boomsma, D.I. Publication year 2000 Abstract ApoE levels and chromosome 19 ApoE polymorphisms were measured in a sample of 156 Dutch families. Each pedigree consisted of parents aged 35-65 years and their twin offspring aged 14-21 years. A significant effect of the chromosome 19 apoE locus on quantitative plasma levels of apolipoprotein E was observed. The ApoE polymorphism explained 16% of the variance in ApoE levels. Tests of association of ApoE levels with the apoC1 locus, which is in complete linkage disequilibrium with the ApoE locus, also showed a significant effect, although the variance explained by ApoCl was only 1%. Examination of the covariance between twins classified according to allele sharing indicates that the association is not due to population stratification, but to a genuine effect of the ApoE locus on levels. However, the ApoE locus accounts for only one-fourth of the genetic variation in ApoE levels. (C) 2000 Wiley-Liss, Inc. Chemicals/CAS: Apolipoproteins E Subject AdolescentAdultAllelesApolipoproteins EChromosomes, Human, Pair 19Enzyme-Linked Immunosorbent AssayFemaleGene FrequencyGenotypeHumansLinkage DisequilibriumMaleMiddle AgedModels, GeneticModels, StatisticalNetherlandsPedigreePhenotypePolymorphism, GeneticTwinsVariation (Genetics) To reference this document use: http://resolver.tudelft.nl/uuid:686d406b-05a4-4275-82c2-cb8c787de845 DOI https://doi.org/10.1002/(sici)1098-2272(200004)18:43.0.co;2-v TNO identifier 235508 ISSN 0741-0395 Source Genetic Epidemiology, 18 (18), 331-340 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.