Title
ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels
Author
Gaubius Instituut TNO Preventie en Gezondheid
Neale, M.C.
de Knijff, P.
Havekes, L.M.
Boomsma, D.I.
Publication year
2000
Abstract
ApoE levels and chromosome 19 ApoE polymorphisms were measured in a sample of 156 Dutch families. Each pedigree consisted of parents aged 35-65 years and their twin offspring aged 14-21 years. A significant effect of the chromosome 19 apoE locus on quantitative plasma levels of apolipoprotein E was observed. The ApoE polymorphism explained 16% of the variance in ApoE levels. Tests of association of ApoE levels with the apoC1 locus, which is in complete linkage disequilibrium with the ApoE locus, also showed a significant effect, although the variance explained by ApoCl was only 1%. Examination of the covariance between twins classified according to allele sharing indicates that the association is not due to population stratification, but to a genuine effect of the ApoE locus on levels. However, the ApoE locus accounts for only one-fourth of the genetic variation in ApoE levels. (C) 2000 Wiley-Liss, Inc. Chemicals/CAS: Apolipoproteins E
Subject
Adolescent
Adult
Alleles
Apolipoproteins E
Chromosomes, Human, Pair 19
Enzyme-Linked Immunosorbent Assay
Female
Gene Frequency
Genotype
Humans
Linkage Disequilibrium
Male
Middle Aged
Models, Genetic
Models, Statistical
Netherlands
Pedigree
Phenotype
Polymorphism, Genetic
Twins
Variation (Genetics)
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DOI
https://doi.org/10.1002/(sici)1098-2272(200004)18:43.0.co;2-v
TNO identifier
235508
ISSN
0741-0395
Source
Genetic Epidemiology, 18 (18), 331-340
Document type
article