Title
Active avoidance behavior in guinea pigs: Effects of physostigmine and scopolamine
Author
Philippens, I.H.C.H.M.
Melchers, B.P.C.
Wolthuis, O.L.
Publication year
1992
Abstract
Behavioral training of guinea pigs by conventional methods, such as used for rats and mice, appears difficult. Hence, only a few behavioral experiments with guinea pigs have been described in the literature. An active avoidance technique in an automated two-way shuttlebox is described using sound as a conditioned (CS) and a tactile stimulus (a stream of air ruffling their fur) as an unconditioned (UCS) stimulus. Acquisition is fairly rapid and reproducible. Doses of physostigmine that caused moderate blood acetylcholinesterase inhibition induced dose-dependent performance decrements. These decrements were counteracted by a sign-free dose of scopolamine.
Subject
Active avoidance
Behavior
Guinea pig
Physostigmine
Scopolamine
Shuttlebox
Acetylcholinesterase
Animal experiment
Avoidance behavior
Drug antagonism
Enzyme activity
Guinea pig
Learning
Male
Acoustic stimulation
Animal
Avoidance learning
Dose-response relationship, Drug
Animalia
Cavia
Cavia porcellus
Sus scrofa
Physostigmine, 57-47-6
Scopolamine, 51-34-3
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http://resolver.tudelft.nl/uuid:67ffff18-1efe-4057-a7d5-b415a78e77fb
DOI
https://doi.org/10.1016/0091-3057(92)90528-n
TNO identifier
231893
ISSN
0091-3057
Source
Pharmacology Biochemistry and Behavior, 42 (42), 285-289
Document type
article