Print Email Facebook Twitter Polymorphism of the blood clot lysis enzyme tissue-type plasminogen activator is associated with myocardial infarction Title Polymorphism of the blood clot lysis enzyme tissue-type plasminogen activator is associated with myocardial infarction Author van der Bom, J.G. de Knijff, P. Bots, M.L. Haverkate, F. Hofman, A. Kluft, C. Grobbee, D.E. Gaubius Instituut TNO Publication year 1996 Abstract Objective: Impaired fibrinolysis has been suggested to be associated with increased risk of myocardial infarction. An insertion/deletion (I/D) polymorphism of the tissue-type plasminogen activator (t-PA) gene has been described which may be associated with impaired fibrinolysis. We studied the association between this polymorphism and the prevalence of myocardial infarction. Design: A population based case control study. Setting: A district of Rotterdam, the Netherlands. Participants: From the cohort that consisted of 7983 men and women aged 55 years and over, we selected 162 subjects with a documented history of myocardial infarction and 258 age matched control subjects without arterial disease. Measurements: All subjects were typed for the Alu sequence insertion/deletion polymorphism located in intron h of the t-PA gene. Results: Allele frequencies were 0.54 for the insertion allele and 0.46 for the deletion allele, and were in Hardy Weinberg equilibrium. Homozygosity for the insertion (n=138) was associated with an increased risk of myocardial infarction compared to homozygosity (n=75) for the deletion: relative risk 2.0(95% CI 1.1, 3.6). Conclusion: These findings suggest an association of the insertion allele of the t-PA gene with the occurrence of myocardial infarction. The I/D polymorphism seems to be a linkage marker for an unknown mutation at, or near, the tPA gene. The insertion allele may reflect an impaired capacity of the fibrinolytic system to respond adequately to acute coronary thrombosis. © Pearson Professional Ltd 1996. Subject Biology To reference this document use: http://resolver.tudelft.nl/uuid:6795c6a3-6529-4050-969f-e6131b566b40 TNO identifier 233691 ISSN 0268-9499 Source Fibrinolysis, 10 (SUPPL. 1), 27-28 Bibliographical note Abstract 89 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.