Print Email Facebook Twitter Synovial inflammation, immune cells and their cytokines in osteoarthritis: A review Title Synovial inflammation, immune cells and their cytokines in osteoarthritis: A review Author de Lange-Brokaar, B.J.E. Ioan-Facsinay, A. van Osch, G.J.V.M. Zuurmond, A.-M. Schoones, J. Toes, R.E.M. Huizinga, T.W.J. Kloppenburg, M. Publication year 2012 Abstract Objective: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is widely accepted that synovial inflammation is a feature of OA. However, the role of immune cells and their cytokines in OA is largely unknown. This narrative systematic review summarizes the knowledge of inflammatory properties, immune cells and their cytokines in synovial tissues (STs) of OA patients. Design: Broad literature search in different databases was performed which resulted in 100 articles. Results: Of 100 articles 33 solely investigated inflammation in OA ST with or without comparison with normal samples; the remaining primarily focussed on rheumatoid arthritis (RA) ST. Studies investigating different severity stages or cellular source of cytokines were sparse. OA ST displayed mild/moderate grade inflammation when investigated by means of haematoxylin and eosin (H&E) staining. Most frequently found cells types were macrophages, T cells and mast cells (MCs). Overall the number of cells was lower than in RA, although the number of MCs was as high as or sometimes even higher than in RA ST. Cytokines related to T cell or macrophage function were found in OA ST. Their expression was overall higher than in normal ST, but lower than in RA ST. Their cellular source remains largely unknown in OA ST. Conclusion: Inflammation is common in OA ST and characterized by immune cell infiltration and cytokine secretion. This inflammation seems quantitatively and qualitatively different from inflammation in RA. Further research is needed to clarify the role of inflammation, immune cells and their cytokines in the pathogenesis of OA. © 2012 Osteoarthritis Research Society International. Subject LifeMHR - Metabolic Health ResearchEELS - Earth, Environmental and Life SciencesHealthy LivingCytokinesHistologyImmune cellsInflammationOsteoarthritisSynovial tissuegamma interferoninterleukin 10interleukin 18interleukin 1betainterleukin 2interleukin 4interleukin 6interleukin 8transforming growth factor betatumor necrosis factor alphacell infiltrationcytokine releasehip arthroplastyimmunocompetent cellimmunohistochemistryinformation retrievalknee arthroscopymacrophagemast cellneedle biopsyosteoarthritispriority journalreviewrheumatoid arthritissynovectomysynovitisT lymphocyte To reference this document use: http://resolver.tudelft.nl/uuid:676bad86-aa77-4191-ba23-8a65a5bfb786 DOI https://doi.org/10.1016/j.joca.2012.08.027 TNO identifier 465809 ISSN 1063-4584 Source Osteoarthritis and Cartilage, 20 (12), 1484-1499 Bibliographical note Chemicals/CAS: gamma interferon, 82115-62-6; interleukin 18, 189304-55-0; interleukin 2, 85898-30-2; interleukin 8, 114308-91-7 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.