Title
Gamma-Ray mutagenesis in bacteriophage T4 is not enhanced by oxygen
Author
Bleichrodt, J.F.
Roos-Verheij, W.S.D.
Medisch Biologisch Laboratorium TNO
Publication year
1979
Abstract
As in the induction of r mutants in bacteriophage T4 by ??-rays, the radiation-induced reversion of T4 amber mutants to wild-type was found to depend on the product of the DNA-repair gene x of the phage. Neither the efficiency of induction of r mutants nor the efficiency of reversion of ambers was enhanced by the presence of oxygen during irradiation. T4 differed in this respect from phage T7, for which no indication has been found that ??-ray mutagenesis results from error-prone repair of DNA damage. Notwithstanding the substantial contribution of misrepair to mutation induction in T4, the efficiency of induction per base-pair observed for irradiation under oxygen was lower than that found previously for T7. Chemicals/CAS: oxygen, 7782-44-7; DNA, Viral; Mutagens; Oxygen, 7782-44-7
Subject
Biology
Oxygen
Animal experiment
Bacteriophage
Gamma radiation
Heredity
In vitro study
Mutagenesis
Mutant
Coliphages
DNA Repair
DNA, Viral
Gamma Rays
Mutagens
Mutation
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TNO identifier
228642
Source
Mutation Research, 61 (2), 121-127
Document type
article