Title
The Dermal Advanced REACH Tool (dART): A Bayesian Model for Dermal Exposure Assessment
Author
McNally, K.
Goede, H.A.
Schinkel, J.
Gorce, J.P.
Warren, N.
Publication year
2022
Abstract
The dermal Advanced REACH Tool (dART) is a tier 2 exposure model for estimating dermal exposure to the hands (mg min-1) for non-volatile liquid and solid-in-liquid products. The dART builds upon the existing ART framework and describes three mass transport processes (deposition (Dhands), direct emission and direct contact (Ehands), and contact transfer (Thands)) that may each contribute to dermal exposure. The mechanistic model that underpins the dART and calibration of the mechanistic model, such that the dimensionless score that results from encoding contextual information about a task into the determinants of the dART can be converted into a prediction of exposure (mg min-1), have been described in previous work. This paper completes the methodological framework of the dART model through placing the mechanistic model within a wider statistical modelling framework. A mixed-effects model, within a Bayesian framework, is presented for modelling the rate of dermal exposure per minute of activity. The central estimate of exposure for a particular task is provided by a calibrated mechanistic model (and thus based upon contextual information about a task). The model also describes between- and within-worker sources of variability in dermal exposure, with prior distributions for variance components based upon the literature. Estimates of exposure based upon informative prior distributions may be updated using measurement data associated with the task. The dART model is demonstrated using three worked examples, where estimates are initially obtained based upon the prior distributions alone, and then refined through accommodating measurement data on the tasks. © 2021 Crown copyright 2021.
Subject
Dermal exposure
Exposure modelling
Skin
Bayesian
Variability
To reference this document use:
http://resolver.tudelft.nl/uuid:64fe00ec-b6fa-4cc6-8779-526d9b5b1efb
DOI
https://doi.org/10.1093/annweh/wxab114
TNO identifier
972345
Source
Annals of work exposures and health, 66 (66), 602-617
Document type
article