Title
Neurobehavioral effects of acute exposure to aromatic hydrocarbons
Author
McKee, R.H.
Lammers, J.H.C.M.
Muijser, H.
Owen, D.E.
Kulig, B.M.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
This article reports the results of neurobehavioral tests on representative aromatic constituents, specifically C9 to C11 species. The testing evaluated effects in several domains including clinical effects, motor activity, functional observations, and visual discrimination performance. Exposures ranging from 600 to 5000 mg/m3, depending on the molecular weights of the specific aromatic constituents, produced minor, reversible effects on the central nervous system (CNS), particularly in the domains of gait and visual discrimination. There was little evidence of effects at lower exposure levels. There was some evidence of respiratory effects at 5000 mg/m3 in 1 study, and there were also minor changes in body weight and temperature. The CNS effects became less pronounced with repeated exposures, corresponding to lower concentrations in the brain of 1 representative substance, 1,2,4-trimethyl benzene (TMB). At high exposure levels, the alkyl benzenes apparently induced their own metabolism, increasing elimination rates. © 2010 The Author(s).
Subject
Biology
Biomedical Research
Aromatic hydrocarbon
Central nervous system depression
Neurotoxicology
Occupational exposure limits
Trimethyl benzene
To reference this document use:
http://resolver.tudelft.nl/uuid:63a5c8b6-b841-49d1-a648-17a8dc5b130e
TNO identifier
364409
ISSN
1091-5818
Source
International Journal of Toxicology, 29 (3), 277-290
Document type
article