Print Email Facebook Twitter Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin Title Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin Author Broekmans, W.M.R. Berendschot, T.T.J.R. Klöpping-Ketelaars, I.A.A. de Vries, A.J. Goldbohm, R.A. Tijburg, L.B.M. Kardinaal, A.F.M. van Poppel, G. TNO Voeding Publication year 2002 Abstract Background: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a general population. Objective: The objective was to investigate the associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein, taking into account potential confounders in a population. Design: Volunteers (n = 376) aged 18-75 y were recruited. In a cross-sectional design, serum (n = 376) and adipose tissue (n = 187) were analyzed for carotenoids, and MP density was measured by spectral fundus reflectance. Results: Mean MP density in the total study group was 0.33 ± 0.15. MP density was 13% higher in men than in women (P < 0.05). Serum and blood concentrations of α-tocopherol, vitamin C, and all carotenoids except lycopene were significantly higher in women. Adipose lutein concentrations were also significantly higher in women than in men. Regression models showed a positive significant association between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations in men after adjustment for age, but no relation in women. In men, serum lutein remained significantly associated with MP density after adjustment for age, total cholesterol, body mass index, and smoking. Conclusion: The associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations are stronger in men than in women. Subject CarotenoidsLuteinMacular degenerationMacular pigmentNetherlandsZeaxanthinalpha tocopherolascorbic acidcarotenoidxanthophyllzeaxanthinadipose tissueadultagedarticleblood leveleye fundusfemalehumanhuman experimentmalenormal humanpigment epitheliumretina macula age related degenerationretina macula lutearisk factorvitamin blood levelAdipose TissueAdolescentAdultAgedalpha-TocopherolAscorbic Acidbeta CaroteneBody Mass IndexCarotenoidsCholesterolCholesterol, HDLCholesterol, LDLFemaleHumansLuteinMacula LuteaMaleMiddle AgedRegression AnalysisRetinal PigmentsSex CharacteristicsSmokingXanthophyllsStaphylococcus phage 187 To reference this document use: http://resolver.tudelft.nl/uuid:6301592f-cefb-4681-b30c-99c491226f0c TNO identifier 236664 ISSN 0002-9165 Source American Journal of Clinical Nutrition, 76 (3), 595-603 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.