Title
Fruits and vegetables and ovarian cancer risk in a pooled analysis of 12 cohort studies
Author
Koushik, A.
Hunter, D.J.
Spiegelman, D.
Anderson, K.E.
Arslan, A.A.
Beeson, W.L.
van den Brandt, P.A.
Buring, J.E.
Cerhan, J.R.
Colditz, G.A.
Fraser, G.E.
Freudenheim, J.L.
Genkinger, J.M.
Goldbohm, R.A.
Hankinson, S.E.
Koenig, K.L.
Larsson, S.C.
Leitzmann, M.
McCullough, M.L.
Miller, A.B.
Patel, A.
Rohan, T.E.
Schatzkin, A.
Smit, E.
Willett, W.C.
Wolk, A.
Zhang, S.M.
Smith-Warner, S.A.
TNO Kwaliteit van Leven
Publication year
2005
Abstract
Because fruits and vegetables are rich in bioactive compounds with potential cancer-preventive actions, increased consumption may reduce the risk of ovarian cancer. Evidence on the association between fruit and vegetable intake and ovarian cancer risk has not been consistent. We analyzed and pooled the primary data from 12 prospective studies in North America and Europe. Fruit and vegetable intake was measured at baseline in each study using a validated food-frequency questionnaire. To summarize the association between fruit and vegetable intake and ovarian cancer, study-specific relative risks (RR) were estimated using the Cox proportional hazards model, and then combined using a random-effects model. Among 560,441 women, 2,130 cases of invasive epithelial ovarian cancer occurred during a maximum follow-up of 7 to 22 years across studies. Total fruit intake was not associated with ovarian cancer risk-the pooled multivariate RR for the highest versus the lowest quartile of intake was 1.06 [95% confidence interval (95% CI), 0.92-1.21; P value, test for trend = 0.73; P value, test for between-studies heterogeneity = 0.74]. Similarly, results for total vegetable intake indicated no significant association (pooled multivariate RR, 0.90; 95% CI, 0.78-1.04, for the highest versus the lowest quartile; P value, test for trend = 0.06; P value, test for between-studies heterogeneity = 0.31). Intakes of botanically defined fruit and vegetable groups and individual fruits and vegetables were also not associated with ovarian cancer risk. Associations for total fruits and vegetables were similar for different histologic types. These results suggest that fruit and vegetable consumption in adulthood has no important association with the risk of ovarian cancer. Copyright © 2005 American Association for Cancer Research.
Subject
Health Nutrition
Food and Chemical Risk Analysis
adult
aged
article
cancer risk
cohort analysis
confidence interval
controlled study
dietary intake
Europe
female
follow up
food intake
fruit
hazard assessment
histology
human
major clinical study
multivariate analysis
North America
ovary cancer
priority journal
questionnaire
risk assessment
vegetable
Adult
Aged
Aged, 80 and over
Cohort Studies
Diet
Europe
Female
Fruit
Humans
Incidence
Middle Aged
North America
Ovarian Neoplasms
Risk Factors
Vegetables
To reference this document use:
http://resolver.tudelft.nl/uuid:6274ccdd-0489-442e-af39-d67912b49f61
DOI
https://doi.org/10.1158/1055-9965.epi-05-0218
TNO identifier
238695
ISSN
1055-9965
Source
Cancer Epidemiology Biomarkers and Prevention, 14 (9), 2160-2167
Document type
article