Print Email Facebook Twitter Determination of polar organophosphorus pesticides in aqueous samples by direct injection using liquid chromatography: Tandem mass spectrometry Title Determination of polar organophosphorus pesticides in aqueous samples by direct injection using liquid chromatography: Tandem mass spectrometry Author Ingelse, B.A. van Dam, R.C.J. Vreeken, R.J. Mol, H.G.J. Steijger, O.M. TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO Publication year 2001 Abstract It was demonstrated that four out of six of the very polar organophosphorus pesticides (OPs), i.e. acephate, methamidophos, monocrotophos, omethoate, oxydemeton-methyl and vamidothion, could not be extracted from water using commonly available SPE cartridges. In addition, GC analysis on all six compounds was found to be troublesome due to their polar and thermolabile character. This initiated the development of an alternative highly sensitive and selective method for the determination of the above mentioned very polar OPs in water, based on LC-MS. Large volume (1 ml) water samples were directly injected onto an RP18 HPLC column with a polar endcapping. The latter was essential for obtaining retention and maintaining column performance under 100% aqueous conditions during the sampling. The compounds were ionized using atmospheric pressure chemical ionization and detected on a tandem mass spectrometer operated in multiple reaction-monitoring mode. The detection limits were in the range of 0.01-0.03 μg/l. Compared to conventional GC methods, the developed LC-MS procedure is very straightforward, fast and more reliable. This application demonstrates the applicability of LC-MS for analysis of polar OPs in surface, ground and drinking water, as a more favourable alternative to GC. © 2001 Elsevier Science B.V. Chemicals/CAS: Insecticides; Organophosphorus Compounds; Water, 7732-18-5 Subject NutritionOrganophosphorus compoundsPesticidesWater analysisAtmospheric pressureIonizationLiquid chromatographyMass spectrometrySensitivity analysisPolar endcappingPesticidesChromatography, GasChromatography, High Pressure LiquidInsecticidesMass SpectrometryOrganophosphorus CompoundsReproducibility of ResultsSensitivity and SpecificityWater To reference this document use: http://resolver.tudelft.nl/uuid:61c508e9-87c7-4c06-b76e-f80c1843bf43 DOI https://doi.org/10.1016/s0021-9673(01)00660-4 TNO identifier 72272 ISSN 0021-9673 Source Journal of Chromatography A, 918 (1), 67-78 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.