Title
Determination of polar organophosphorus pesticides in aqueous samples by direct injection using liquid chromatography: Tandem mass spectrometry
Author
Ingelse, B.A.
van Dam, R.C.J.
Vreeken, R.J.
Mol, H.G.J.
Steijger, O.M.
TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2001
Abstract
It was demonstrated that four out of six of the very polar organophosphorus pesticides (OPs), i.e. acephate, methamidophos, monocrotophos, omethoate, oxydemeton-methyl and vamidothion, could not be extracted from water using commonly available SPE cartridges. In addition, GC analysis on all six compounds was found to be troublesome due to their polar and thermolabile character. This initiated the development of an alternative highly sensitive and selective method for the determination of the above mentioned very polar OPs in water, based on LC-MS. Large volume (1 ml) water samples were directly injected onto an RP18 HPLC column with a polar endcapping. The latter was essential for obtaining retention and maintaining column performance under 100% aqueous conditions during the sampling. The compounds were ionized using atmospheric pressure chemical ionization and detected on a tandem mass spectrometer operated in multiple reaction-monitoring mode. The detection limits were in the range of 0.01-0.03 μg/l. Compared to conventional GC methods, the developed LC-MS procedure is very straightforward, fast and more reliable. This application demonstrates the applicability of LC-MS for analysis of polar OPs in surface, ground and drinking water, as a more favourable alternative to GC. © 2001 Elsevier Science B.V. Chemicals/CAS: Insecticides; Organophosphorus Compounds; Water, 7732-18-5
Subject
Nutrition
Organophosphorus compounds
Pesticides
Water analysis
Atmospheric pressure
Ionization
Liquid chromatography
Mass spectrometry
Sensitivity analysis
Polar endcapping
Pesticides
Chromatography, Gas
Chromatography, High Pressure Liquid
Insecticides
Mass Spectrometry
Organophosphorus Compounds
Reproducibility of Results
Sensitivity and Specificity
Water
To reference this document use:
http://resolver.tudelft.nl/uuid:61c508e9-87c7-4c06-b76e-f80c1843bf43
DOI
https://doi.org/10.1016/s0021-9673(01)00660-4
TNO identifier
72272
ISSN
0021-9673
Source
Journal of Chromatography A, 918 (1), 67-78
Document type
article