Title
Nature and histogenesis of sulfite-induced gastric lesions in rats
Author
Beems, R.B.
Spit, B.J.
Koeter, H.B.W.M.
Feron, V.J.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
1982
Abstract
A variety of gastric lesions can be induced in rats by sodium metabisulfite, including the formation of scattered hyperplastic glands in the fundic mucosa which are exclusively lined by large uniform cells, laden with acidophilic granules. Light and electron microscopy, as enzyme histochemistry, showed that the cells lining these glands are hyperactive chief cells, containing a huge amount of pepsinogen granules. A time-sequence study revealed that the hyperactive chief cells arise from preexisting chief cells but are also capable of proliferation. The occurrence of glands exclusively lined by chief cells is highly unusual since mucous cells rather than chief cells are considered to be involved in the regeneration of gastric epithelium after physical or chemical damage. Chemicals/CAS: sodium metabisulfite, 7681-57-4, 7757-74-6; sulfurous acid, 7782-99-2; thiamine, 59-43-8, 67-03-8; sodium metabisulfite, 7681-57-4; Sulfites
Subject
Sodium metabisulfite
Sulfurous acid
Thiamine
Animal experiment
Electron microscopy
Histology
Hyperplasia
Nonhuman
Rat
Stomach
Stomach chief cell
Stomach erosion
Stomach lesion
Ultrastructure
Animal
Cell Division
Diet
Female
Gastric Fundus
Gastric Mucosa
Histocytochemistry
Hyperplasia
Male
Rats
Rats, Inbred Strains
Stomach
Sulfites
Time Factors
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TNO identifier
229297
ISSN
0014-4800
Source
Experimental and Molecular Pathology, 36 (3), 316-325
Document type
article