Print Email Facebook Twitter Nature and histogenesis of sulfite-induced gastric lesions in rats Title Nature and histogenesis of sulfite-induced gastric lesions in rats Author Beems, R.B. Spit, B.J. Koeter, H.B.W.M. Feron, V.J. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1982 Abstract A variety of gastric lesions can be induced in rats by sodium metabisulfite, including the formation of scattered hyperplastic glands in the fundic mucosa which are exclusively lined by large uniform cells, laden with acidophilic granules. Light and electron microscopy, as enzyme histochemistry, showed that the cells lining these glands are hyperactive chief cells, containing a huge amount of pepsinogen granules. A time-sequence study revealed that the hyperactive chief cells arise from preexisting chief cells but are also capable of proliferation. The occurrence of glands exclusively lined by chief cells is highly unusual since mucous cells rather than chief cells are considered to be involved in the regeneration of gastric epithelium after physical or chemical damage. Chemicals/CAS: sodium metabisulfite, 7681-57-4, 7757-74-6; sulfurous acid, 7782-99-2; thiamine, 59-43-8, 67-03-8; sodium metabisulfite, 7681-57-4; Sulfites Subject Sodium metabisulfiteSulfurous acidThiamineAnimal experimentElectron microscopyHistologyHyperplasiaNonhumanRatStomachStomach chief cellStomach erosionStomach lesionUltrastructureAnimalCell DivisionDietFemaleGastric FundusGastric MucosaHistocytochemistryHyperplasiaMaleRatsRats, Inbred StrainsStomachSulfitesTime Factors To reference this document use: http://resolver.tudelft.nl/uuid:61a1b4da-068f-4a46-af49-e3736565b2a7 TNO identifier 229297 ISSN 0014-4800 Source Experimental and Molecular Pathology, 36 (3), 316-325 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.