Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells

Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells

Heeney, J.L.
van Els, C.
de Vries, P.
ten Haaft, P.
Otting, N.
Koornstra, W.
Boes, J.
Dubbes, R.
Niphuis, H.
Dings, M.
Cranage, M.
Norley, S.
Jonker, M.
Bontrop, R.E.
Osterhaus, A.

1994

To evaluate the effectiveness of vaccine protection from infected cells from another individual of the same species, vaccinated rhesus macaques (Macaca mulatta) were challenged with peripheral blood mononuclear cells from another animal diagnosed with acquired immune deficiency syndrome (AIDS). Half of the simian immunodeficiency virus (SIV)-vaccinated animals challenged were protected, whereas unprotected vaccinates progressed as rapidly to AIDS. Protection was unrelated to either total antibody titers to human cells, used in the production of the vaccine, to HLA antibodies or to virus neutralizing activity. However, analysis of the serotype of each animal revealed that all animals protected against cell-associated virus challenge were those which were SIV vaccinated and which shared a particular major histocompatibility complex (MHC) class I allele (Mamu-A26) with the donor of the infected cells. Cytotoxic T lymphocytes (CTL) specific for SIV envelope protein were detected in three of four protected animals vs. one of four unprotected animals, suggesting a possible role of MHC class I-restricted CTL in protection from infected blood cells. These findings have possible implications for the design of vaccines for intracellular pathogens such as human immunodeficiency virus (HIV).

Glycoprotein gp 120
Major histocompatibility antigen class 1
Measles vaccine
Neutralizing antibody
Virus vaccine
Acquired immune deficiency syndrome
Animal cell
Animal experiment
Animal model
Antibody titer
Controlled study
Cytotoxic t lymphocyte
Major histocompatibility complex restriction
Mononuclear cell
Nonhuman
Polymerase chain reaction
Provocation test
Rhesus monkey
Serotype
Simian immunodeficiency virus
Vaccination
Virus neutralization
Amino Acid Sequence
Animals
Histocompatibility Antigens Class I
Human
Macaca mulatta
Molecular Sequence Data
Sequence Homology, Amino Acid
Simian Acquired Immunodeficiency Syndrome
SIV
Viral Vaccines
Histocompatibility Antigens Class I
Viral Vaccines

http://resolver.tudelft.nl/uuid:6185b90b-df49-4bef-8b3f-a0e3dbda01be

https://doi.org/10.1084/jem.180.2.769

280582

0022-1007

Journal of Experimental Medicine, 180 (180), 769-774

article