Title
Cigarette smoking, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma
Author
TNO Kwaliteit van Leven
van Dijk, B.A.C.
Schouten, L.J.
Oosterwijk, E.
Hulsbergen van de,
Kaa, C.A.
Kiemeney, L.A.L.M.
Goldbohm, R.A.
Schalken, J.A.
van den Brandt, P.A.
Publication year
2006
Abstract
We investigated whether smoking is associated with mutations in the Von Hippel-Lindau (VHL) gene in 337 cases of sporadic renal cell carcinoma (RCC) among 120 852 people followed for 11.3 years; the findings suggest that smoking causes RCC independently of VHL gene mutations. © 2006 Cancer Research. Chemicals / CAS: adenine, 22177-51-1, 2922-28-3, 73-24-5; cytosine, 71-30-7; guanine, 69257-39-2, 73-40-5; thymine, 65-71-4; Von Hippel-Lindau Tumor Suppressor Protein, EC 6.3.2.19
Subject
Food and Chemical Risk Analysis
Cigarette smoking
Cohort study
Renal cell carcinoma
The Netherlands
Von Hippel-Lindau gene mutations
Adenine
Cytosine
Guanine
Thymine
Adult
Aged
Cigarette smoking
Clear cell carcinoma
Cohort analysis
Dose response
Female
Follow up
Gene
Gene mutation
Human
Human tissue
Kidney carcinoma
Major clinical study
Male
Netherlands
Nucleic acid base substitution
Priority journal
Risk factor
Von hippel lindau gene
Aged
Carcinoma, Renal Cell
Cohort Studies
Female
Humans
Japan
Kidney Neoplasms
Male
Middle Aged
Multivariate Analysis
Mutation
Risk Factors
Smoking
Von Hippel-Lindau Tumor Suppressor Protein
To reference this document use:
http://resolver.tudelft.nl/uuid:615520f2-cba4-4986-bc4b-771c56853780
DOI
https://doi.org/10.1038/sj.bjc.6603281
TNO identifier
239420
ISSN
0007-0920
Source
British Journal of Cancer, 95 (95), 374-377
Document type
article