Title
Food matrix and isoflavones bioavailability in early post menopausal women: A European clinical study
Author
TNO Kwaliteit van Leven
Chanteranne, B.
Branca, F.
Kardinaal, A.
Wahala, K.
Braesco, V.
Ladroite, P.
Brouns, F.
Coxam, V.
Publication year
2008
Abstract
The estrogenic effects of soy isoflavones (IF) on symptoms of menopause are of particular interest. The aim of the present study was to improve compliance of IF in two IF-enriched foods providing the same IF circulating levels in postmenopausal women. Forty-two healthy postmenopausal women (mean age: 53.28 years) were recruited for a randomized, crossover, multicenter trial conducted in the Netherlands, Italy and France. Over 18 days, volunteers were assigned to two groups and supplemented with two different IF-enriched foods (100 mg IF aglycones/two servings). The first group had to eat two biscuits daily for three days. After a wash-out period (11 d), they received cereal bars for three days. The second group started with the cereal bars and finished with biscuits. After IF intake, plasma and urinary levels of genistein, daidzein, O desmethyl angolensin and equol significantly increased and returned to baseline level after the washout period. There was no difference between biscuits and cereals bars intake, as shown by group values at each end of experimental period (day 4 or day 18). Both matrixes are comparable in terms of IF-circulating levels and could be used independently. © 2008 Chanteranne et al, publisher and licensee Dove Medical Press Ltd.
Subject
Healthy Living
Healthy for Life
Physiological Sciences
Bioavailability
Equol
Food processing
Postmenopausal women
Soy isoflavones
Aglycone
Daidzein
Equol
Flavone
Genistin
Isoflavone
Oxygen desmethyl angolensin
Unclassified drug
Adult
Article
Bioavailability
Blood level
Cereal
Clinical trial
Controlled clinical trial
Controlled study
Female
Food composition
Food intake
Human
Multicenter study
Normal human
Postmenopause osteoporosis
Randomized controlled trial
Soybean
Urine level
Biological Availability
Bone and Bones
Cross-Over Studies
Female
Food, Fortified
Humans
Isoflavones
Middle Aged
Patient Compliance
Phytoestrogens
Postmenopause
Soy Foods
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http://resolver.tudelft.nl/uuid:60729bc2-42ef-4ee2-a5ca-fee39387f5d3
TNO identifier
241270
ISSN
1176-9092
Source
Clinical Interventions in Aging, 3 (3), 711-718
Document type
article