Title
Probiotic bacteria and the immune system: mechanistic insights and therapeutic implications
Author
Mariman, R.
Publication year
2013
Abstract
This thesis aimed to provide insight into the role of microbiota-host interactions in the regulation of mucosal and systemic immunity in the context of IBD. Regulation of microbiota composition (e.g. by probiotics and prebiotics) offers the possibility to modulate immune responses and contribute to the prevention and treatment of (autoimmune) - diseases. By evaluating immune modulation capacities of probiotics with genome-wide gene expression profiling in both in vivo and in vitro models, novel mechanisms were identified in which probiotic bacteria modulate immune responses under conditions of homeostasis and inflammation. These new insights will allow more rational selection and validation of probiotic usage in a variety of clinical conditions.
Subject
Healthy Living
Biomedical Innovation
Dendritic cells
Inflammatory bowel disease
Toll-like receptors
Trinitrobenzene sulfonic acid
Probiotics
Immune-modulation
To reference this document use:
http://resolver.tudelft.nl/uuid:604d3b8c-86a3-4034-9ab1-1fa571eb5a60
TNO identifier
536288
Publisher
Universiteit, Leiden
ISBN
9789461086181
Document type
doctoral thesis