Print Email Facebook Twitter Relevance of parameters related to fertility and reproduction in toxicity testing Title Relevance of parameters related to fertility and reproduction in toxicity testing Author Koëter, H.B.W.M. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1983 Abstract Toxicity data of 37 compounds tested in both a subchronic study and one or more studies focused on reproduction were evaluated to obtain information on the significance of fertility and reproduction parameters in setting no-effect levels (NEL). It appeared that a) the test system aimed at reproduction and development was more sensitive than the subchronic study for 35% of the selected compounds and was equally sensitive for another 35%; b) for 65% of these compounds parameters related to reproduction and development were at least codecisive in determining the minimal-effect level (MEL); c) for 21% of all compounds, parameters related to reproduction were the most sensitive and therefore decisive for the MEL. It was concluded that reproduction in its broadest sense is a very sensitive tool in toxicity testing. The possibilities of either applying a simple screen of fertility and reproduction at an early stage of toxicity testing or incorporating fertility and reproduction parameters in the current subchronic study are discussed. Subject Antibiotic agentChemical agentChlorinated hydrocarbonHeavy metalInsecticideChemical teratogenesisDrug toxicityFemale genital systemFertilityFetusIntoxicationMale genital systemNonhumanPregnancyReproductionShort surveyToxicity testingAnimalDrug Evaluation, PreclinicalFemaleFertilityPregnancyRatsReproductionSupport, Non-U.S. Gov'tToxicologyZoologyMedicineGeneeskundePharmacology To reference this document use: http://resolver.tudelft.nl/uuid:5efcfc2a-0dd2-43bf-8549-f034158c3122 TNO identifier 229347 ISSN 0271-3586 Source American Journal of Industrial Medicine, 4 (1-2), 81-86 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.