Print Email Facebook Twitter Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo Title Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo Author van den Berg, K.J. van Raaij, J.A.G.M. Bragt, P.C. Notten, W.R.F. Medisch Biologisch Laboratorium TNO Publication year 1991 Abstract Previous results in experimental systems have suggested that hydroxylated PCBs may decrease thyroid hormone levels through associative interaction with transthyretin. In the present paper it was investigated whether this property was also shared by various industrial chemicals, mainly pesticides. In total, 65 compounds from 12 chemical groups were analyzed for direct interference with the T4 binding site of transthyretin using a competitive binding assay. Sixty per cent of the compounds were competitive at a concentration level of 100 μM. Relatively strong interactions were observed by several chlorophenols, chlorophenoxy acids and nitrophenols, as well as by individual compounds such as hexachlorobenzene, dicofol, bromoxynil and tetrachlorohydroquinone. Examples from these chemical groups, e.g. pentachlorophenol, 2,4-dichlorophenoxybutyric acid, dinoseb and bromoxynil, also reduced plasma TT4 levels in rats. In addition, bromoxynil decreased plasma TT3 levels. The results suggest the existence of a number of halogenated industrial chemicals with a potential for lowering plasma thyroid hormone levels through interference with hormone transport carriers. Subject 2,4-DBBromoxynilDinosebIndustrial compoundsPCPPlasma TT3Plasma TT4Thyroid hormone carriersTransthyretin4 (2,4 dichlorophenoxy)butyric acid4 chlorophenoxyacetic acid derivativeBromoxynilChlorophenol derivativeDicofolDinosebHalogenated hydrocarbonHexachlorobenzeneLiothyronineNitrophenol derivativePentachlorophenolPolychlorinated biphenylPrealbuminTetrachlorohydroquinoneThyroxineUnclassified drugAnimal cellAnimal experimentLiothyronine blood levelMaleNonhumanPriority journalRatThyroxine blood levelAnimalBinding, CompetitiveHydrocarbons, HalogenatedMalePrealbuminProtein BindingRatsRats, Inbred StrainsReceptors, Thyroid HormoneThyroxineAnimalia To reference this document use: http://resolver.tudelft.nl/uuid:5e51deb0-5c4e-456f-915f-95997c163106 DOI https://doi.org/10.1007/bf01973497 TNO identifier 231477 ISSN 0340-5761 Source Archives of Toxicology, 65 (1), 15-19 Bibliographical note Correspondence Address: Van den Berg, K.J.; Dept. Occupational Toxicology, TNO Medical Biological Lab., PO Box 45, 2280 AA Rijswijk, Netherlands Chemicals/CAS: Hydrocarbons, Halogenated; Prealbumin; Receptors, Thyroid Hormone; Thyroxine, 7488-70-2 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.