Title
Glucagon receptors: Are they present on human blood cells?
Author
van Hinsbergh, V.W.M.
Nooijen, W.J.
Kempen, H.J.M.
Gaubius instituut TNO
Publication year
1982
Abstract
Binding of glucagon to and its degradation by human mononuclear leukocytes and erythrocytes was investigated. Labeled glucagon binds to these cells, but can be displaced only by unlabeled glucagon at pharmacologically high concentrations. It is concluded that glucagon binding to human blood cells does not represent receptors of physiological importance and is of no value to the determination of glucagon sensitivity in man. Chemicals/CAS: Glucagon, 9007-92-5; Receptors, Cell Surface; Receptors, Glucagon
Subject
drug receptor
glucagon receptor
insulin i 125
radioisotope
blood and hemopoietic system
endocrine system
erythrocyte
glucagon i 125
glucagon i 127
human cell
in vitro study
leukocyte
monocyte
normal human
Animal
Blood Cells
Erythrocytes
Glucagon
Human
Liver
Lymphocytes
Monocytes
Rats
Receptors, Cell Surface
Receptors, Glucagon
To reference this document use:
http://resolver.tudelft.nl/uuid:5c4ee9c3-85bd-40bd-a32e-9648d6bfb611
TNO identifier
229232
ISSN
0018-5043
Source
Hormone and Metabolic Research, 14 (2), 65-68
Document type
article