Print Email Facebook Twitter Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: A diet-controlled intervention study Title Effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate, testosterone, and estradiol levels in middle-aged men and postmenopausal women: A diet-controlled intervention study Author Sierksma, A. Sarkola, T. Eriksson, C.J.P. van der Gaag, M.S. Grobbee, D.E. Hendriks, H.F.J. TNO Voeding Publication year 2004 Abstract Background: Moderate alcohol consumption is inversely associated with cardiovascular diseases. Changes in hormone levels might in part help explain the positive health effect. This study was performed to examine the effect of moderate alcohol consumption on plasma dehydroepiandrosterone sulfate (DHEAS), testosterone, and estradiol levels. Methods: In a randomized, diet-controlled, crossover study, 10 middle-aged men and 9 postmenopausal women, all apparently healthy, nonsmoking, and moderate alcohol drinkers, consumed beer or no-alcohol beer with dinner during two successive periods of 3 weeks. During the beer period, alcohol intake equaled 40 and 30 g per day for men and women, respectively. The total diet was supplied and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period, in which the subjects were not allowed to drink alcoholic beverages. At the end of each of the two experimental periods, fasting blood samples were collected in the morning. Results: Moderate alcohol consumption increased plasma DHEAS level by 16.5% (95% confidence interval, 8.0-24.9), with similar changes for men and women. Plasma testosterone level decreased in men by 6.8% (95% confidence interval, -1.0 - -12.5), but no effect was found in women. Plasma estradiol level was not affected. Serum high-density lipoprotein cholesterol level increased by 11.7% (95% confidence interval, 7.3-16.0), with similar changes for men and women. The overall alcohol-induced relative changes in DHEAS, testosterone, and estradiol correlated positively with the relative increase in high-density lipoprotein cholesterol (adjusted for the relative change in body weight); however, findings were only borderline significant for DHEAS and estradiol (r =0.44, p = 0.08; r = 0.32, p = 0.21; and r = 0.46, p = 0.06, respectively). Conclusions: A protective effect of moderate alcohol consumption for cardiovascular disease risk may in part be explained by increased plasma DHEAS level. Subject HealthPhysiological SciencesAlcoholDehydroepiandosterone Sulfate (DHEAS)EstradiolHDL CholesterolTestosteronealcoholamstel bieramstel malt bierestradiolhigh density lipoprotein cholesterolprasterone sulfatetestosteroneadultalcohol consumptionalcoholic beveragearticlebeerblood samplingbody weightcardiovascular diseaseclinical articleclinical trialconfidence intervalcontrolled clinical trialcontrolled studycorrelation analysiscrossover procedurediet restrictiondietary intakedisease associationfemaleheart protectionhormone blood levelhumanmalepostmenopausepriority journalrandomizationrandomized controlled trialAlcohol DrinkingBeerConfidence IntervalsCross-Over StudiesDehydroepiandrosterone SulfateDietEstradiolFemaleHumansLinear ModelsLipoproteins, HDLMaleMiddle AgedPostmenopauseTestosterone To reference this document use: http://resolver.tudelft.nl/uuid:5a55ebc7-7ede-4b01-bda5-55ec1ffa705c DOI https://doi.org/10.1097/01.alc.0000125356.70824.81 TNO identifier 237747 ISSN 0145-6008 Source Alcoholism: Clinical and Experimental Research, 28 (5), 780-785 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.