Print Email Facebook Twitter The effect of moderate alcohol consumption on fat distribution and adipocytokines Title The effect of moderate alcohol consumption on fat distribution and adipocytokines Author Beulens, J.W.J. van Beers, R.M. Stolk, R.P. Schaafsma, G. Hendriks, H.F.J. TNO Kwaliteit van Leven Publication year 2006 Abstract Objective: To investigate the effect of moderate alcohol consumption on fat distribution, adipose tissue secreted proteins (adiponectin and resistin), and insulin sensitivity in healthy middle-aged men with abdominal obesity. Research Methods and Procedures: Thirty-four healthy men between 35 and 70 years old, with increased waist circumference (≥94 cm), participated in a randomized, controlled cross-over design trial. They drank 450 mL of red wine (40 grams of alcohol) or 450 mL of de-alcoholized red wine daily during 4 weeks. At the end of each treatment period, fat distribution, adipose tissue proteins, and insulin sensitivity index (ISI) were measured. Results: Subcutaneous and abdominal fat contents and body weight did not change after 4 weeks of moderate alcohol consumption. Liver fat (quip index) was slightly higher after consumption of red wine (6.8 ±0.1) as compared with de-alcoholized red wine (6.5 ±0.1) but not significantly different (p = 0.09). Plasma adiponectin concentration increased (p < 0.01) to 6.0 ± 0.1 μg/mL after 28 days of moderate alcohol consumption compared with de-alcoholized red wine (5.5 ±0.1 μg/mL). Serum resistin concentrations and ISI were not affected by alcohol consumption. Percentage changes in serum resistin correlated signifi cantly with changes in ISI (r = -0.69, p < 0.01), whereas this correlation was not present between changes in plasma adiponectin and ISI (r = 0.31, p = 0.22). Discussion: Moderate alcohol consumption for 4 weeks is not associated with differences in subcutaneous and abdominal fat contents or body weight. Thus, the 10% increase in adiponectin was not associated with a change in fat distribution or body weight change. Copyright © 2006 NAASO. Subject HealthBiomedical ResearchAbdominal obesityAdiponectinInsulin sensitivityResistinUltrasoundadiponectininsulinresistinabdominal fatabdominal subcutaneous fatadipose tissueadultagedarticlebloodbody compositionclinical trialcontrolled clinical trialcontrolled studycrossover proceduredrinking behaviorhumanmalemetabolismmiddle agedobesityrandomized controlled trialsecretionAbdominal FatAdiponectinAdipose TissueAdultAgedAlcohol DrinkingBody CompositionCross-Over StudiesHumansInsulinMaleMiddle AgedObesityResistinSubcutaneous Fat, Abdominal To reference this document use: http://resolver.tudelft.nl/uuid:5a2a7f8d-716e-4cc0-a799-affb25322048 DOI https://doi.org/10.1038/oby.2006.8 TNO identifier 239055 ISSN 1930-7381 Source Obesity, 14 (1), 60-66 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.