Title
Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in type 2 diabetic men
Author
Manders, R.J.
Koopman, R.
Sluijsmans, W.E.
van den Berg, R.
Verbeek, K.
Saris, W.H.
Wagenmakers, A.J.
van Loon, L.J.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
This study examined postprandial plasma insulin and glucose responses after co-ingestion of an insulinotropic protein (Pro) hydrolysate with and without additional free leucine with a single bolus of carbohydrate (Cho). Male patients with long-standing Type 2 diabetes (n = 10) and healthy controls (n = 10) participated in 3 trials in which plasma glucose, insulin, and amino acid responses were determined after the ingestion of beverages of different composition (Cho: 0.7 g/kg carbohydrate, Cho+Pro: 0.7 g/kg carbohydrate with 0.3 g/kg protein hydrolysate, or Cho+Pro+Leu: 0.7 g/kg carbohydrate, 0.3 g/kg protein hydrolysate and 0.1 g/kg free leucine). Plasma insulin responses [expressed as area under the curve (AUC)] were 141 and 204% greater in patients with Type 2 diabetes and 66 and 221% greater in the controls in the Cho+Pro and Cho+Pro+Leu trials, respectively, compared with those in the Cho trial (P < 0.05). The concomitant plasma glucose responses were 15 and 12% lower in the patients with Type 2 diabetes and 92 and 97% lower in the control group in the Cho+Pro and Cho+Pro+Leu trials, respectively, compared with those in the Cho trial (P < 0.05). Plasma leucine concentrations correlated with the insulin response in all subjects (r = 0.43, P < 0.001). We conclude that co-ingestion of a protein hydrolysate with or without additional free leucine strongly augments the insulin response after ingestion of a single bolus of carbohydrate, thereby significantly reducing postprandial blood glucose excursions in patients with long-standing Type 2 diabetes. © 2006 American Society for Nutrition.
Subject
Biology
Analytical research
Amino acids
Insulin
Postprandial glucose
Type 2 diabetes
amino acid
carbohydrate
glucose
insulin
leucine
metformin
protein hydrolysate
sulfonylurea
amino acid blood level
area under the curve
article
body mass
controlled study
demography
glucose blood level
human
ingestion
insulin blood level
insulin like activity
insulin response
male
non insulin dependent diabetes mellitus
Administration, Oral
Amino Acids
Beverages
Blood Glucose
Body Mass Index
Body Size
Diabetes Mellitus, Type 2
Diabetic Diet
Humans
Leucine
Male
Middle Aged
Postprandial Period
Protein Hydrolysates
Reference Values
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http://resolver.tudelft.nl/uuid:59eacb5f-fd1f-4b06-be7d-ed0a4787646d
TNO identifier
239261
ISSN
0022-3166
Source
Journal of Nutrition, 136 (5), 1294-1299
Document type
article