Print Email Facebook Twitter The interplay of glutathione-related processes in antioxidant defense Title The interplay of glutathione-related processes in antioxidant defense Author Cnubben, N.H.P. Rietjens, I.M.C.M. Wortelboer, H. van Zanden, J.J. van Bladeren, P.J. Instituut CIVO-Toxicologie en Voeding TNO Publication year 2001 Abstract This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathways. Enhanced expression of various enzymes involved in GSH metabolism, including glutathione peroxidases, γ-glutamyl cysteinyl synthetase (γ-GCS), glutathione S-transferases (GST) and membrane proteins belonging to the ATP-binding cassette family, such as the multidrug resistance associated protein, have all been demonstrated to play a prominent role in cellular resistance towards oxidative stress. This review stresses the fact that a co-ordinate interplay between these systems is essential for efficient protection against oxidative stress. © 2001 Elsevier Science B.V. All rights reserved. Subject EnvironmentAntioxidantGlutathioneGlutathione S-transferasesMultidrug resistance associated proteinOxidative stress To reference this document use: http://resolver.tudelft.nl/uuid:59cc7ae4-4107-4d31-8094-9a8d50c275d4 DOI https://doi.org/10.1016/s1382-6689(01)00077-1 TNO identifier 41998 ISSN 1382-6689 Source Environmental Toxicology and Pharmacology, 10 (4), 141-152 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.