Print Email Facebook Twitter Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma Title Carotenoid and vitamin intake, von Hippel-Lindau gene mutations and sporadic renal cell carcinoma Author van Dijk, B.A.C. Schouten, L.J. Oosterwijk, E. Kaa, C.A. Kiemeney, L.A.L.M. Goldbohm, R.A. Schalken, J.A. van den Brandt, P.A. TNO Kwaliteit van Leven Publication year 2008 Abstract Objective: We investigated whether dietary carotenoid and vitamin intake and supplemental vitamin use were inversely associated with RCC risk and with Von Hippel-Lindau (VHL)-gene mutations in clear-cell renal cell carcinoma (RCC). Methods: The Netherlands Cohort Study on diet and cancer (NLCS) includes 120,852 persons, who completed a self-administered food-frequency questionnaire in 1986. After 11.3 years of follow-up, 284 cases and a random sample of 4,095 persons (subcohort) with complete data were included in multivariable analyses using a case-cohort approach. VHL gene mutational analysis was complete for 225 cases. Rate ratios and corresponding 95% confidence intervals were estimated using Cox proportional hazard models, while adjusting for age, sex, smoking, body mass index, and a history of hypertension. Results: We observed no association for dietary carotenoid and vitamin intake and RCC risk, and a somewhat increased risk with supplemental vitamin E, AD, and multivitamin use. Results were suggestive of higher RRs for alpha-carotene, beta-cryptoxanthin, folate, and supplemental vitamin C and multivitamin intake for wildtype VHL tumors compared to VHL-mutated tumors. Conclusions: There was no association of carotenoid, vitamin or supplemental vitamin intake and RCC risk. These associations should be investigated by others to confirm the current observations. © 2007 Springer Science+Business Media B.V. Subject HealthRenal cell carcinomaSupplementsVon Hippel-Lindau gene mutationsalpha carotenealpha tocopherolascorbic acidbeta cryptoxanthinfolic acidvon Hippel Lindau proteinadultbody masscancer riskfollow upgene mutationkidney carcinomamajor clinical studyvitamin intakevitamin supplementationAgedCarcinoma, Renal CellCarotenoidsCase-Control StudiesCohort StudiesDietary SupplementsFemaleHumansKidney NeoplasmsMaleMiddle AgedNetherlandsNutrition SurveysProportional Hazards ModelsRiskVitaminsvon Hippel-Lindau Disease To reference this document use: http://resolver.tudelft.nl/uuid:59b7c35e-1b6b-4893-b170-d93e513ee486 DOI https://doi.org/10.1007/s10552-007-9078-5 TNO identifier 240671 ISSN 0957-5243 Source Cancer Causes and Control, 19 (2), 125-134 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.