Print Email Facebook Twitter The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays Title The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays Author Vinken, M. Doktorova, T. Ellinger-Ziegelbauer, H. Ahr, H.-J. Lock, E. Carmichael, P. Roggen, E. van Delft, J. Kleinjans, J. Castell, J. Bort, R. Donato, T. Ryan, M. Corvi, R. Keun, H. Ebbels, T. Athersuch, T. Sansone, S.-A. Rocca-Serra, P. Stierum, R. Jennings, P. Pfaller, W. Gmuender, H. Vanhaecke, T. Rogiers, V. TNO Kwaliteit van Leven Publication year 2008 Abstract Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The Sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing the carcinogenic potential of chemical compounds in a pan-European context. This paper provides an in-depth analysis of the complexity of choosing suitable reference compounds used for creating and fine-tuning the in vitro carcinogenicity assays. First, a number of solid criteria for the selection of the model compounds are defined. Secondly, the strategy followed, including resources consulted, is described and the selected compounds are briefly illustrated. Finally, limitations and problems encountered during the selection procedure are discussed. Since selecting an appropriate set of chemicals is a frequent impediment in the early stages of similar research projects, the information provided in this paper might be extremely valuable. Crown Copyright © 2008. Subject BiologyPhysiological SciencescarcinoGENOMICSChemical carcinogenesisFP6 projectGenomicsGenotoxic carcinogenMetabolomicsMetabonomicsModel compoundsNon-genotoxic carcinogenREACHSelection criteria1,3 butadiene2 nitrofluorene2,3,7,8 tetrachlorodibenzo para dioxinaflatoxin B1alkanonearsenate sodiumasbestosbenzo[a]pyrenebromodichloromethanecadmium derivativechemical compoundchloroprenechlorothalonildichromate sodiumdimethylnitrosamineisobutyl nitritemethapyrilenemonuronnifedipineochratoxinphenobarbitalphorbol 13 acetate 12 myristatepiperonyl butoxidepirinixic acidpotassium bromates (1,2 dichlorovinyl)cysteinestreptozocintolbutamideunindexed drugvinyl chloridecarcinogenicitygenomicshumanin vitro studymedical informationmedical researchmodelnonhumanpriority journalreviewscreeningAnimal Testing AlternativesCarcinogenicity TestsEuropean UnionGene Expression ProfilingGenomicsHazardous SubstancesInternational CooperationToxicogeneticsAnimalia To reference this document use: http://resolver.tudelft.nl/uuid:591fd53a-c3b2-4723-a765-2f551c0b9009 DOI https://doi.org/10.1016/j.mrrev.2008.04.006 TNO identifier 240979 ISSN 1383-5742 Source Mutation Research - Reviews in Mutation Research, 659 (3), 202-210 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.