Title
Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery
Author
Schippers, E.F.
Berbée, J.F.P.
van Disseldorp, I.M.
Versteegh, M.I.M.
Havekes, L.M.
Rensen, P.C.N.
van Dissel, J.T.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
Objective: Experimental models show that apolipoprotein CI (apoCI) binds and enhances the inflammatory response to endotoxin. We studied in patients undergoing cardiopulmonary bypass surgery (CPB) and experiencing endotoxemia during reperfusion whether plasma apoCI levels correlate with the inflammatory response and perioperative cytokine release. Design: Prospective, observational, clinical cohort study. Setting: Operating room (OR) and intensive care unit (ICU) of a university hospital. Patients: One hundred fifty-nine consecutive patients > 18 years of age (66% males (n = 105), median age 65 and 67 years for males and females, respectively) undergoing elective cardiothoracic surgery with cardiopulmonary bypass. Interventions: None. Measurements: Baseline apoCI, apoCIII, total cholesterol and triglyceride levels, and perioperative endotoxin and TNF-α levels were determined. Results: High preoperative plasma apoCI, but not apoCIII, levels were associated (p < 0.05) with increased perioperative levels of TNF-α in patients experiencing endotoxemia. This association was not observed in patients without endotoxemia. Conclusion: High plasma apoCI is positively related to proinflammatory response in patients experiencing endotoxemia and confirms the observations in animal models. © 2008 The Author(s).
Subject
Biology
Biomedical Research
Aged
Apolipoprotein C-I
Cardiac Surgical Procedures
Cardiopulmonary Bypass
Cholesterol
Endotoxemia
Female
Humans
Intraoperative Care
Male
Middle Aged
Postoperative Complications
Predictive Value of Tests
Surgical Procedures, Elective
Tumor Necrosis Factor-alpha
ApoCI
Cardiopulmonary bypass
Endotoxemia
Endotoxin
SIRS
TNF-α
To reference this document use:
http://resolver.tudelft.nl/uuid:58ddf6f5-f385-4449-99df-3abbb7a83cf2
DOI
https://doi.org/10.1007/s00134-008-1077-9
TNO identifier
89644
ISSN
0342-4642
Source
Intensive Care Medicine, 34 (8), 1492-1497
Document type
article