Print Email Facebook Twitter Food-dependent disintegration of immediate release fosamprenavir tablets: In vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system Title Food-dependent disintegration of immediate release fosamprenavir tablets: In vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system Author Brouwers, J. Anneveld, B. Goudappel, G.J. Duchateau, G. Annaert, P. Augustijns, P. Zeijdner, E. Publication year 2011 Abstract In the present study, we demonstrated the value of two advanced tools, the TNO gastric and small Intestinal Model (TIM-1) and magnetic resonance imaging (MRI), for the in vitro evaluation of food-dependent disintegration of immediate release fosamprenavir tablets. Upon introduction of a tablet with the nutritional drink Scandishake Mix® in the stomach compartment of TIM-1, simulating the fed state, disintegration and fosamprenavir dissolution were significantly postponed compared to the fasted state (lag time 80 ± 23 min). This resulted in a lag in the appearance of bioaccessible fosamprenavir (<5% during the first 2 h), even though the nutritional state did not significantly alter the cumulative bioaccessibility after 5 h. These results were in agreement with the previously observed postprandial delay in gastric fosamprenavir tablet disintegration and subsequent amprenavir absorption in healthy volunteers. Therefore, TIM-1 can be used in tablet development to identify food-induced disintegration issues causing unexpected clinical behavior. From a mechanistic perspective, we applied MRI to illustrate impaired water ingress in fosamprenavir tablets immersed in the nutritional drink compared to simulated gastric fluid. This effect may be attributed to both competition between nutritional components and the tablet for the available water (indicated by reduced rotational and translational diffusion) as well as the possible formation of a food-dependent precipitation layer on the HPMC-coated tablet. © 2010 Elsevier Inc. All rights reserved. Subject LifePHS - Pharmacokinetics & Human StudiesEELS - Earth, Environmental and Life SciencesNutritionFed stateFormulation developmentImmediate release tabletsMagnetic resonance imagingTablet disintegrationGastrointestinal model To reference this document use: http://resolver.tudelft.nl/uuid:5874a9c7-1029-4f60-8c5d-d9d0bcdce489 DOI https://doi.org/10.1016/j.ejpb.2010.10.009 TNO identifier 427538 ISSN 0939-6411 Source European Journal of Pharmaceutics and Biopharmaceutics, 77 (2), 313-319 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.