Print Email Facebook Twitter Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development Title Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development Author van der Greef, J. Adourian, A. Muntendam, P. McBurney, R.N. TNO Kwaliteit van Leven Publication year 2006 Abstract Too few drug discovery projects generate a marketed drug product, often because preclinical studies fail to predict the clinical experience with a drug candidate. Improving the success of preclinical-to-clinical translation is of paramount importance in optimizing the pharmaceutical value chain. Here, we advance the case for a molecular systems approach to crossing the preclinical-to-clinical translational chasm and for metabolomic analysis of readily accessible bodyfluids as a key technology in translational activities. © 2006. Subject BiologyAnalytical researchbiological markerdrug metabolitenew drugbioinformaticsbody fluiddata basedecision makingdrug determinationdrug efficacydrug marketingdrug researchdrug safetyhumanmedical technologymetabolomicsmultiple sclerosisnon insulin dependent diabetes mellitusnonhumanosteoarthritisphenotypepostmarketing surveillanceproteomicsreviewserologystructure activity relation To reference this document use: http://resolver.tudelft.nl/uuid:5850bbf0-cb1e-414b-ab1d-c0d54647895b DOI https://doi.org/10.1016/j.ddtec.2006.05.003 TNO identifier 239279 ISSN 1740-6749 Source Drug Discovery Today: Technologies, 3 (2), 205-211 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.