Title
Age-and sex-related interactions between insulin-like growth factor-I promoter polymorphisms and IGF-I levels
Author
van Turenhout, E.C.
Deijen, J.B.
Koppes, L.L.J.
van Mechelen, W.
Twisk, J.W.R.
Drent, M.L.
Publication year
2011
Abstract
The present study explored sex-and age-related interactions of IGF-I polymorphisms with IGF-I serum levels. In 2000 data on IGF-I promoter polymorphism and IGF-I level were available of 344 (mean age 36; 162 men) and 6 years later in 287 subjects (133 men). As the sample sizes of groups of subjects with IGF-I genotypes 192/192, 190/192, 192/194 and 192/196 were large enough to be analyzed, the relationship between these specific genotypes and IGF-I-level was determined. The results indicated that in women aged 36 IGF-I levels for genotype 190/192 (mean 29.24 nmol/l) were higher than those for genotypes 192/192 (mean 24.29), 192/194 (mean 24.61) and 192/196 (mean 23.93). Male IGFI levels were decreased in 2006 compared to 2000 for genotypes 192/192 (mean decline - 3.67), 192/194 (mean decline - 1.61), 192/196 (mean decline - 4.18), but not for 190/192. Female IGF-I levels were decreased for genotypes 192/192 (mean decline - 1.85) and 190/192 (mean decline - 4.64), but not for 192/194 and 192/196. Thus females with genotype 190/192 have higher IGF-I levels, while females with genotypes 192/194 or 192/196 and males with genotype 190/192 do not show a decline of IGF-I level. © van Turenhout et al.
Subject
Organisation
WH - Work & Health
BSS - Behavioural and Societal Sciences
Workplace
Genotype
IGF-I polymorphisms
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http://resolver.tudelft.nl/uuid:584b04a6-da87-4acd-acbb-659db8648b0b
DOI
https://doi.org/10.2174/1876528901104010015
TNO identifier
430093
ISSN
1876-5289
Source
Open Neuroendocrinology Journal, 4, 15-21
Document type
article