Title
The absorption of a new sustained release furazolidone formulation from the digestive tract of piglets and calves.
Author
Hekman, P.
Rietveld, E.C.
Instituut voor Landbouwkundig Onderzoek en Biochemische Produkten TNO
Publication year
1988
Abstract
Chyme concentrations and total recoveries of furazolidone (5 mg/kg body-weight) were determined by a HPLC-method, after oral administration of two different furazolidone formulations to piglets (n = 6) and pre-ruminant calves (n = 8), provided with an ileal re-entrant canula. Additional blood samples were taken from the calves to measure the time dependent plasma levels of furazolidone. In the case of the normal crystalline preparation, the results indicate an almost complete absorption of the drug from the upper parts of the digestive tract. In both species, 96-99% of the dose had been absorbed by the time it reached the end of the ileum. The mean ileal recovery of the newly developed furazolidone formulation in calves and piglets was 14% and 38%, respectively. In calves the observed maximum plasma concentrations of furazolidone after oral application of the sustained release formulation were 14 times lower than with the normal crystalline preparation.
Subject
Nutrition
Delayed Action Preparations
Furazolidone
Animal
Cattle
Comparative study
Delayed release formulation
Intestine absorption
Male
Metabolism
Oral drug administration
Stomach juice
Swine
Administration, Oral
Digestive Tract Contents
Furazolidone
Male
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TNO identifier
230698
ISSN
0165-2176
Source
Veterinary Quarterly, 10 (4), 265-269
Document type
article