Title
Weight fluctuation during childhood and cardiometabolic risk at young adulthood
Author
van de Langenberg, D.
Hoekstra, T.
Twisk, J.W.R.
van Wouwe, J.P.
Hirasing, R.A.
Renders, C.M.
de Kroon, M.L.A.
Publication year
2015
Abstract
Objectives To test the hypothesis that greater weight fluctuation between 2 and 6 years is associated with an increase in weight measures (such as body mass index [BMI]) and cardiometabolic risk in young adulthood. Study design Weight fluctuation (determined by BMI SD scores) was measured at least 3 times between the ages of 2 and 6 years in 166 girls and 116 boys from the Terneuzen Birth Cohort. Cardiometabolic risk factors in young adulthood include components of the metabolic syndrome and weight. The extent of weight fluctuation was determined by assessing each individual's SE (or variation) around each individual's linear regression slope (or weight slope). The obtained variation scores were subsequently related to adult BMI, other weight measures, and cardiometabolic risk factors. Results In girls, greater weight fluctuation between 2 and 6 years was statistically significantly related to greater adult weight measures (1.08; 95% CI 1.01-1.15) and nonsignificantly with the metabolic syndrome. For boys weight fluctuation was not associated with adult weight (1.04; 95% CI 0.97-1.11), but weight slope was statistically significantly associated with adult overweight. Conclusions The results suggest that weight fluctuations during early childhood are predictive for adult overweight in girls. For boys weight slope instead of weight fluctuation is predictive for adult overweight.
Subject
Life
CH - Child Health
ELSS - Earth, Life and Social Sciences
Healthy for Life
Health
Healthy Living
Adult
Adulthood
Body mass
Cardiometabolic risk
Child
Female
Human
Major clinical study
Male
Metabolic syndrome X
Obesity
Prospective study
Sex difference
Waist circumference
Waist to height ratio
Weight fluctuation
Young adult
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DOI
https://doi.org/10.1016/j.jpeds.2014.10.012
TNO identifier
522528
ISSN
0022-3476
Source
Journal of Pediatrics, 166 (2), 313-318.e1
Document type
article