Title
Assessment of dermal exposure of greenhouse workers to the pesticide bupirimate
Author
Medisch Biologisch Laboratorium TNO
Jongen, M.J.M.
Engel, R.
Leenheers, L.H.
Publication year
1992
Abstract
An HPLC method was developed for estimation of dermal exposure of greenhouse workers to the pesticide bupirimate. Chromatography was performed on a cyano-modified silica column with methanol-water (6:4 by volume) containing 5 g/L ammonium sulfate as eluent. UV detection at 310 nm was used for quantitation. Dermal exposure was assessed by letting the workers wear cotton gloves and by measuring foliar dislodgable residues in the greenhouses as potential exposure. The analytical procedure was validated for measurement of bupirimate on cotton gloves and in solutions used for the estimation of foliar dislodgable residues. Gloves were extracted with methanol. Recovery of bupirimate from fortified gloves was complete. Methanol extracts with one volume of water added and solutions containing dislodgable residues were injected directly onto the HPLC system. The limit of detection was 30 μg/L. Between-day coefficients of variation were 7 and 4% at concentrations of 0.6 and 28 mg/L, respectively. Chemicals/CAS: ammonium sulfate, 7783-20-2; bupirimate, 41483-43-6; methanol, 67-56-1; bupirimate, 41483-43-6; Mesylates; Pesticide Residues.
Subject
Ammonium sulfate
Bupirimate
Fungicide
Methanol
Pesticide
Unclassified drug
Extraction
Glove
High performance liquid chromatography
Human
Occupational exposure
Priority journal
Residue analysis
Skin permeability
Ultraviolet spectrophotometry
Administration, Cutaneous
Adult
Chromatography, High Pressure Liquid
Human
Mesylates
Occupational Exposure
Pesticide Residues
Plants
Spectrophotometry
Support, Non-U.S. Gov't
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TNO identifier
231831
ISSN
0146-4760
Source
Journal of Analytical Toxicology, 16 (16), 60-62
Document type
article