Print Email Facebook Twitter Dietary supplementation of different doses of NUTRIOSE®FB, a fermentable dextrin, alters the activity of faecal enzymes in healthy men Title Dietary supplementation of different doses of NUTRIOSE®FB, a fermentable dextrin, alters the activity of faecal enzymes in healthy men Author van den Heuvel, E.G.H.M. Wils, D. Pasman, W.J. Saniez, M.H. Kardinaal, A.F.M. TNO Kwaliteit van Leven Publication year 2005 Abstract Background: It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE®FB is a dextrin that is not completely hydrolysed and absorbed in the small intestine, due to many α-1.6 linkages and the presence of non-digestible glucoside linkages (e. g. α-1.2 and α-1.3). To be beneficial for 'colonic' health effective NUTRIOSE®FB must reach the cecum in some form. Aim of the study: To estimate how much non digested NUTRIOSE®FB is fermented and to determine the fibrelike effect of the wheat dextrin NUTRIOSE ®FB by analysing enzymatic activity in faeces. Methods: In a randomized, double-blind,multiple dose, placebo-controlled, combined cross-over and parallel trial, 20 healthy men (age 31.7 ± 9.1 yrs; BMI 24.5 ± 2.9 kg •m-2 received different treatments. One group of ten subjects consumed on top of their diet 10, 30 and 60 g daily of NUTRIOSE ®FB or maltodextrin (placebo). The other group of 10 subjects consumed 15, 45 and 80 g daily. Each dose was consumed for 7 days. On the last two days of each of the 7-day period, faeces were collected in which the enzymatic activity and NUTRIOSE®FB residue were analysed. Results: As expected, the faecal residue of NUTRIOSE®FB non-linearly increased with the dose of NUTRIOSE®FB to approximately 13% of 80 g/d. Compared with the placebo, 30, 45, 60 and 80 g/d of NUTRIOSE®FB increased the concentration of α-glucosidase significantly. All daily doses of NUTRIOSE®FB (10 g/d to 80 g/d) led to significant changes in concentration of β-glucosidase. Conclusions: The small amount of the residue of NUTRIOSE®FB in the faeces suggests that approximately 87% or more of NUTRIOSE®FB is digested or fermented in the gastrointestinal tract. Fermentation of NUTRIOSE®FB led to an increased faecal concentration of α- and β-glucosidase. © Steinkopff Verlag 2005. Subject HealthBiomedical Researchα-glucosidaseβ-glucosidaseDextrinNUTRIOSE®FBalpha glucosidasebeta glucosidasedextrinmaltodextrinnutrioseplaceboadultarticleclinical trialcontrolled clinical trialcontrolled studycrossover procedurediet supplementationdigestiondose responsedouble blind procedureenzyme activityenzyme assayfecesfeces analysisfermentationfibergastrointestinal tracthumanmalemultiple drug dosenormal humanparallel designrandomized controlled trialwheatAdultbeta-GlucosidaseColonCross-Over StudiesDextrinsDietary CarbohydratesDietary FiberDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodFecesFermentationGlucosidasesHumansMaleMiddle AgedTriticum aestivum To reference this document use: http://resolver.tudelft.nl/uuid:5316dd76-516e-4ba4-87fe-e1fdb83dbfa8 DOI https://doi.org/10.1007/s00394-005-0552-0 TNO identifier 238751 ISSN 1436-6207 Source European Journal of Nutrition, 44 (7), 445-451 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.