Title
Dietary supplementation of different doses of NUTRIOSE®FB, a fermentable dextrin, alters the activity of faecal enzymes in healthy men
Author
van den Heuvel, E.G.H.M.
Wils, D.
Pasman, W.J.
Saniez, M.H.
Kardinaal, A.F.M.
TNO Kwaliteit van Leven
Publication year
2005
Abstract
Background: It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE®FB is a dextrin that is not completely hydrolysed and absorbed in the small intestine, due to many α-1.6 linkages and the presence of non-digestible glucoside linkages (e. g. α-1.2 and α-1.3). To be beneficial for 'colonic' health effective NUTRIOSE®FB must reach the cecum in some form. Aim of the study: To estimate how much non digested NUTRIOSE®FB is fermented and to determine the fibrelike effect of the wheat dextrin NUTRIOSE ®FB by analysing enzymatic activity in faeces. Methods: In a randomized, double-blind,multiple dose, placebo-controlled, combined cross-over and parallel trial, 20 healthy men (age 31.7 ± 9.1 yrs; BMI 24.5 ± 2.9 kg •m-2 received different treatments. One group of ten subjects consumed on top of their diet 10, 30 and 60 g daily of NUTRIOSE ®FB or maltodextrin (placebo). The other group of 10 subjects consumed 15, 45 and 80 g daily. Each dose was consumed for 7 days. On the last two days of each of the 7-day period, faeces were collected in which the enzymatic activity and NUTRIOSE®FB residue were analysed. Results: As expected, the faecal residue of NUTRIOSE®FB non-linearly increased with the dose of NUTRIOSE®FB to approximately 13% of 80 g/d. Compared with the placebo, 30, 45, 60 and 80 g/d of NUTRIOSE®FB increased the concentration of α-glucosidase significantly. All daily doses of NUTRIOSE®FB (10 g/d to 80 g/d) led to significant changes in concentration of β-glucosidase. Conclusions: The small amount of the residue of NUTRIOSE®FB in the faeces suggests that approximately 87% or more of NUTRIOSE®FB is digested or fermented in the gastrointestinal tract. Fermentation of NUTRIOSE®FB led to an increased faecal concentration of α- and β-glucosidase. © Steinkopff Verlag 2005.
Subject
Health
Biomedical Research
α-glucosidase
β-glucosidase
Dextrin
NUTRIOSE®FB
alpha glucosidase
beta glucosidase
dextrin
maltodextrin
nutriose
placebo
adult
article
clinical trial
controlled clinical trial
controlled study
crossover procedure
diet supplementation
digestion
dose response
double blind procedure
enzyme activity
enzyme assay
feces
feces analysis
fermentation
fiber
gastrointestinal tract
human
male
multiple drug dose
normal human
parallel design
randomized controlled trial
wheat
Adult
beta-Glucosidase
Colon
Cross-Over Studies
Dextrins
Dietary Carbohydrates
Dietary Fiber
Dietary Supplements
Dose-Response Relationship, Drug
Double-Blind Method
Feces
Fermentation
Glucosidases
Humans
Male
Middle Aged
Triticum aestivum
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http://resolver.tudelft.nl/uuid:5316dd76-516e-4ba4-87fe-e1fdb83dbfa8
DOI
https://doi.org/10.1007/s00394-005-0552-0
TNO identifier
238751
ISSN
1436-6207
Source
European Journal of Nutrition, 44 (7), 445-451
Document type
article