Print Email Facebook Twitter One-year time-sequence inhalation toxicity study of vinyl chloride in rats. II. Morphological changes in the respiratory tract, ceruminous glands, brain, kidneys, heart and spleen Title One-year time-sequence inhalation toxicity study of vinyl chloride in rats. II. Morphological changes in the respiratory tract, ceruminous glands, brain, kidneys, heart and spleen Author Feron, V.J. Kroes, R. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1979 Abstract Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppm vinyl chloride monomer (VCM), 7 h/day, 5 days/week, for a period of 52 weeks. After 4, 13, 26 and 52 weeks each time 10 rats/sex/group were killed and subjected to extensive examinations. The present paper describes the morphological changes observed in the respiratory tract, ceruminous glands, brain, kidneys, heart and spleen. The VCM-effects included increased degree of tubular nephrosis, mild focal degeneration of the myocard, and increased haematopoietic activity in the spleen. In addition, primary tumours were found in the brain (ependymoma), lungs (papillary adenoma and mesenchymal type of tumour), ceruminous glands (mainly keratinized squamous cell carcinomas), and nasal cavity (carcinomas of the olfactory epithelium, carcino-sarcoma, esthesioneuroepithelioma). Chemicals/CAS: vinyl chloride, 75-01-4; Vinyl Chloride, 75-01-4; Vinyl Compounds Subject Vinyl chlorideAnimal experimentBrainCarcinogenesisCentral nervous systemDrug toxicityHeartHeart injuryInhalational drug administrationIntoxicationKidneyKidney injuryMicroscopyRatRespiratory systemSkin glandSpleenAnimalBrainCerumenExocrine GlandsFemaleKidneyMaleMyocardiumNeoplasms, ExperimentalRatsRespiratory SystemSex FactorsSpleenTime FactorsVinyl ChlorideVinyl Compounds To reference this document use: http://resolver.tudelft.nl/uuid:52b2361b-28bb-49f0-8795-2aa419145687 TNO identifier 228722 ISSN 0300-483X Source Toxicology, 13 (2), 131-141 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.