Title
Tissue type plasminogen activator, atherosclerosis and the risk of myocardial infarction
Author
van der Bom, J.G.
Bots, M.L.
Haverkate, F.
Meijer, P.
Kluft, C.
Gaubius Instituut TNO
Publication year
1996
Abstract
Objective: We studied the association of plasma concentrations of tissuetype plasminogen activator (t-PA) and the, until now single documented polymorphism of the t-PA gene, with degree of atherosclerosis and the prevalence of myocardial infarction. Design: Cross-sectional, population-based case control study. Setting: A district of Rotterdam, the Netherlands. Participants: 110 cases of myocardial infarction and 255 controls, free of cardiovascular disease were drawn from the Rotterdam Study, a populationbased cohort study of 7983 subjects of 55 years and older. Subjects using anticoagulant drugs were not selected. Measurements: The ankle to arm blood pressure ratio (AAI), a indicator for atherosclerosis and t-PA antigen and activity (Stabilytc) and the insertion/deletion polymorphism in intron h of the t-PA gene (obtained in blood cells) were determined. Results are adjusted for age and gender. Results: Homoxygosity for the insertion was associated with twice as many cases of myocardial infarction compared to homo/ygosily for the deletion (relative risk 2.24 (95% CI 1.11,4.50). The polymorphism was not associated with plasma concentrations of t-PA antigen or activity. T-PA antigen was positively associated with myocardial infarction, the risk in the upper half of the distribution was 1.61 (95% CI 1.03,2.53) compared to the lower half. When adjusted for total and HDL cholesterol, BMI and blood pressure, the risk markedly attenuated. T-PA activity was not associated with the risk of myocardial infarction. T-PA antigen and activity were both positively associated with decrease in AAI, 2.88 ng/ml (SE 1.67, p = 0.09) and 0.38 IU/ml (SE 0.20, p = 0.06) respectively per unit decrease in AAI. Conclusion: This study provides evidence for an association of the insertion allele of the insertion/deletion polymorphism of the l-PA gene with non-fatal myocardial infarction, independent of plasma levels of t-PA. Increased levels of t-PA antigen and activity may be due to vascular disease.
Subject
Biology
To reference this document use:
http://resolver.tudelft.nl/uuid:5267fb64-6f82-40aa-8df0-58a24d62b90d
TNO identifier
233684
ISSN
0268-9499
Source
Fibrinolysis, 10 (SUPPL. 3), 3
Document type
article