Title
Arginine-dependent acid resistance in Salmonella enterica serovar typhimurium
Author
TNO Defensie en Veiligheid
Kieboom, J.
Abee, T.
Publication year
2006
Abstract
Salmonella enterica serovar Typhimurium does not survive a pH 2.5 acid challenge under conditions similar to those used for Escherichia coli (J. W. Foster, Nat. Rev. Microbiol. 2:898-907, 2004). Here, we provide evidence that S. enterica serovar Typhimurium can display arginine-dependent acid resistance (AM) provided the cells are grown under anoxic conditions and not under the microaerobic conditions used for assessment of AR in E. coli. The role of the arginine decarboxylase pathway in Salmonella AR was shown by the loss of AR in mutants lacking adiA, which encodes arginine decarboxylase; adiC, which encodes the arginine-agmatine antiporter; or adiY, which encodes an AraC-like regulator. Transcription of adiA and adiC was found to be dependent on AdiY, anaerobiosis, and acidic pH. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Subject
Antiporter
Acidity
AdiA gene
AdiC gene
AdiY gene
Anaerobic growth
Anoxia
Bacterial gene
Bacterium mutant
Enzyme activity
Escherichia coli
Genetic transcription
Nonhuman
Salmonella enterica
Adaptation, Physiological
Hydrogen-Ion Concentration
Mutation
Salmonella typhimurium
Adia
Escherichia coli
Salmonella
Salmonella enterica
Salmonella enterica subsp. enterica serovar Typhimurium
Agmatine, 306-60-5
Arginine decarboxylase, 9024-77-5
Arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3
Arginine decarboxylase, EC 4.1.1.19
Carboxy-Lyases, EC 4.1.1.-
Oxygen, 7782-44-7
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DOI
https://doi.org/10.1128/jb.00323-06
TNO identifier
239406
ISSN
0021-9193
Source
Journal of Bacteriology, 188 (188), 5650-5653
Document type
article