Title
Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: Differences between older men and women
Author
Mennen, L.I.
de Maat, M.P.M.
Schouten, E.G.
Kluft, C.
de Jong, P.T.V.M.
Hofman, A.
Grobbee, D.E.
Gaubius Instituut TNO
Publication year
1997
Abstract
Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VU[. The association of serum-triglycerides with factor VII may differ between the genotypes, but the results of earlier studies were inconsistent and did not include older people. We studied FVII, triglycerides and the R/Q353 polymorphism in the Rotterdam Study. In 1158 older subjects (489 men and 669 women) FVII:C, factor VII:Chr, serum-triglycerides and the R/Q353-genotype were determined. In women triglycerides were positively associated with FVII:Chr and FVII:C (FVII:Chr: β = 12.4% PP/mmol/L, CI: 10.3-14.5; FVII:C: β = 13.1% PP/mmol/L, CI: 10.4-15.8). These associations varied by genotype (FVII:Chr:RR: β = 11.7, CI: 9.6-13.8, RQ/QQ: β = 7.9, CI: 4.6-11.2; FRII:C: RR: β = 12.5, CI: 9.5-15.5, RQ/QQ: β = 6.4, CI: In men, the associations of FVII:Chr and FVII:C with triglycerides were weaker (FVII:Chr: β = 5.9, CI: 4.1-7.7; FVII:C: β = 8.7, CI: 6.2-11.2). There was no difference between the genotype groups. These results suggest that only in older women the strength of the association of factor VII with serum-triglycerides varies according to genotype of the R/Q353 polymorphism.
Subject
Biology
Blood clotting factor 7
Triacylglycerol
Adult
Aged
Allele
Cardiovascular risk
Controlled study
Genetic association
Genetic polymorphism
Genotype
Human cell
Major clinical study
Regression analysis
Sex difference
Triacylglycerol blood level
Aging
Alleles
Factor VII
Female
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Sex Characteristics
Triglycerides
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TNO identifier
234018
ISSN
0340-6245
Source
Thrombosis and Haemostasis, 78 (3), 984-986
Document type
article