Print Email Facebook Twitter Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: Differences between older men and women Title Coagulation factor VII, serum-triglycerides and the R/Q353 polymorphism: Differences between older men and women Author Mennen, L.I. de Maat, M.P.M. Schouten, E.G. Kluft, C. de Jong, P.T.V.M. Hofman, A. Grobbee, D.E. Gaubius Instituut TNO Publication year 1997 Abstract Coagulation factor VII activity (FVII:C) is a risk indicator for cardiovascular disease. It is related to serum-triglycerides and the R/Q353 polymorphism (alleles R and Q) in the gene coding for factor VII is strongly associated with factor VU[. The association of serum-triglycerides with factor VII may differ between the genotypes, but the results of earlier studies were inconsistent and did not include older people. We studied FVII, triglycerides and the R/Q353 polymorphism in the Rotterdam Study. In 1158 older subjects (489 men and 669 women) FVII:C, factor VII:Chr, serum-triglycerides and the R/Q353-genotype were determined. In women triglycerides were positively associated with FVII:Chr and FVII:C (FVII:Chr: β = 12.4% PP/mmol/L, CI: 10.3-14.5; FVII:C: β = 13.1% PP/mmol/L, CI: 10.4-15.8). These associations varied by genotype (FVII:Chr:RR: β = 11.7, CI: 9.6-13.8, RQ/QQ: β = 7.9, CI: 4.6-11.2; FRII:C: RR: β = 12.5, CI: 9.5-15.5, RQ/QQ: β = 6.4, CI: In men, the associations of FVII:Chr and FVII:C with triglycerides were weaker (FVII:Chr: β = 5.9, CI: 4.1-7.7; FVII:C: β = 8.7, CI: 6.2-11.2). There was no difference between the genotype groups. These results suggest that only in older women the strength of the association of factor VII with serum-triglycerides varies according to genotype of the R/Q353 polymorphism. Subject BiologyBlood clotting factor 7TriacylglycerolAdultAgedAlleleCardiovascular riskControlled studyGenetic associationGenetic polymorphismGenotypeHuman cellMajor clinical studyRegression analysisSex differenceTriacylglycerol blood levelAgingAllelesFactor VIIFemaleGenotypeHumansMaleMiddle AgedPolymorphism, GeneticSex CharacteristicsTriglycerides To reference this document use: http://resolver.tudelft.nl/uuid:50e225ef-fef6-4a20-a65f-ff9ef100cb98 TNO identifier 234018 ISSN 0340-6245 Source Thrombosis and Haemostasis, 78 (3), 984-986 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.