Title
Effect of Moderate Alcohol Consumption on Adiponectin, Tumor Necrosis Factor-α, and Insulin Sensitivity
Author
Sierksma, A.
Patel, H.
Ouchi, N.
Kihara, S.
Funahashi, T.
Heine, R.J.
Grobbee, D.E.
Kluft, C.
Hendriks, H.F.J.
TNO Preventie en Gezondheid
Publication year
2004
Abstract
OBJECTIVE - Epidemiological studies suggest that moderate alcohol consumers have enhanced insulin sensitivity and a reduced risk of type 2 diabetes. Adiponectin, an adipocyte-derived plasma protein, has been found to be negatively associated with adiposity and positively associated with insulin sensitivity. Moderate alcohol consumption may increase adiponectin, which in turn causes a decrease of tumor necrosis factor (TNF)-α. A decreased TNF-α level may consequently increase insulin sensitivity. RESEARCH DESIGN AND METHODS - To test this hypothesis, we performed a randomized crossover partially diet-controlled study. A total of 23 healthy middle-aged male subjects consumed daily four glasses of whisky (40 g ethanol) or tap water with dinner during two successive periods of 17 days. RESULTS - Moderate alcohol consumption increased plasma adiponectin level (11%; P = 0.002) but did not affect plasma TNF-α level. An increase in insulin sensitivity index was observed in an insulin-resistant subgroup (21%; P = 0.11), which positively correlated with the relative alcohol-induced increase in plasma adiponectin level (r = 0.73, P = 0.02). CONCLUSIONS - The experimental results are in agreement with observational data. Moderate alcohol consumption improved insulin sensitivity in relatively insulin-resistant middle-aged men, an effect that may be mediated through alcohol-induced increases in adiponectin.
Subject
Health
Physiological Sciences
Adiponectin
C peptide
Cholesterol
Cytokine
Fatty acid
Glucose
High density lipoprotein cholesterol
Insulin
Insulin receptor
Low density lipoprotein cholesterol
Tap water
Triacylglycerol
Tumor necrosis factor alpha
Adipose tissue
Adult
Alcohol consumption
Cholesterol blood level
Clinical trial
Controlled study
Crossover procedure
Diabetes mellitus
Diet restriction
Glucose blood level
Insulin sensitivity
Non insulin dependent diabetes mellitus
Normal human
Randomized controlled trial
Risk factor
Whiskey
Adiponectin
Aged
Alcohol Drinking
Body Mass Index
Body Weight
Cross-Over Studies
Glucose Clamp Technique
Humans
Hyperinsulinism
Insulin
Insulin Resistance
Intercellular Signaling Peptides and Proteins
Male
Middle Aged
Proteins
Regression Analysis
Tumor Necrosis Factor-alpha
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http://resolver.tudelft.nl/uuid:5047511f-c248-47ca-b1de-8f1abe29a81b
DOI
https://doi.org/10.2337/diacare.27.1.184
TNO identifier
237588
ISSN
0149-5992
Source
Diabetes Care, 27 (1), 184-189
Document type
article