Title
Use of nutrigenomics endpoints in dietary interventions
Author
Hendriks, H.F.J.
Publication year
2013
Abstract
In this paper, the nutrigenomics approach is discussed as a research tool to study the physiological effects of nutrition and consequently how nutrition affects health and disease (endpoints). Nutrigenomics is the study of the effects of foods and food constituents on gene expression; the analyses include analysis of mRNA, proteins and metabolites. Nutrigenomics may be useful in dealing with the challenges that nutrition research is facing; by integrating the description of numerous active genes and metabolic pathways stronger evidence and new biomarkers for subtle nutritional effects may be obtained. Also, a new definition of disease and health may be needed. The use of tests challenging homoeostasis is being proposed to help define health. Challenge tests may be able to demonstrate in a better way subtle beneficial effects of nutrition on health. The paper describes some basic concepts relevant to nutrition research as well as some of the possibilities that are offered by nutrigenomics technology. Some of its applications are described. Copyright © The Author 2013.
Subject
Life
PHS - Pharmacokinetics & Human Studies
EELS - Earth, Environmental and Life Sciences
Biomedical Innovation
Biology
Healthy Living
Anti-inflammatory
Challenge testing
Nutrigenomics
Nutrition intervention
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http://resolver.tudelft.nl/uuid:4f809ef6-d9bb-497c-9be2-f35547a93c05
DOI
https://doi.org/10.1017/s0029665113001304
TNO identifier
477626
ISSN
0029-6651
Source
Proceedings of the Nutrition Society, 72 (3), 348-351
Document type
article