Print Email Facebook Twitter Dietary folate and folate vitamers and the risk of prostate cancer in the Netherlands Cohort Study Title Dietary folate and folate vitamers and the risk of prostate cancer in the Netherlands Cohort Study Author Verhage, B.A.J. Cremers, P. Schouten, L.J. Goldbohm, R.A. van den Brandt, P.A. Publication year 2012 Abstract Purpose: The aim of the present study was to examine the association between intake of folate, and specific folate vitamers, and the risk of advanced and total prostate cancer. Methods: The association between dietary folate and prostate cancer risk was evaluated in The Netherlands Cohort Study (NLCS) on diet and cancer, conducted among 58,279 men ages 55-69 years at baseline. Information on diet was collected at baseline by means of food frequency questionnaires. Incident cases were identified by record linkage with regional cancer registries and the Dutch National Database of Pathology Reports. After 17.3 years of follow-up, 3,669 incident prostate cancer cases, of which 1,290 advanced cases, and 2,336 male subcohort members were available for case-cohort analyses. Results: Dietary folate was not associated with prostate cancer risk, nor with the risk of advanced prostate cancer, among men in the NLCS cohort (HR = 1.05, 95 % CI: 0.87-1.26 and HR = 1.09, 95 % CI: 0.88-1.35, respectively, for the highest quintile of folate intake vs. the lowest quintile). Specific folate vitamers were neither associated with the risk of prostate cancer or risk of advanced prostate cancer. Conclusions: Our results do not support an association of dietary folate or specific folate vitamers on the risk of prostate cancer, or advanced prostate cancer. © 2012 Springer Science+Business Media Dordrecht. Subject HumanLS - Life StyleBSS - Behavioural and Societal SciencesHealthy for LifeHealthHealthy LivingCohort studyEpidemiologyFolateFolate vitamersOne-carbon metabolismProstate cancer To reference this document use: http://resolver.tudelft.nl/uuid:4f343cb1-3a81-42c0-bb3f-da65a1c34b4d DOI https://doi.org/10.1007/s10552-012-0079-7 TNO identifier 473614 ISSN 0957-5243 Source Cancer Causes and Control, 23 (12), 2003-2011 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.