Print Email Facebook Twitter Combination of dietary factors in relation to breast-cancer occurrence Title Combination of dietary factors in relation to breast-cancer occurrence Author van 't Veer, P. van Leer, E.M. Rietdijk, A. Kok, F.J. Schouten, E.G. Hermus, R.J.J. Sturmans, F. Instituut CIVO-Toxicologie en Voeding TNO Publication year 1991 Abstract Combinations of dietary factors were studied in relation to breast-cancer occurrence among 133 breast cancer cases and 289 population controls in The Netherlands. Dietary factors were classified according to their possible mechanism of action, i.e., relating either to the intestinal microflora (total fat, fiber, fermented milk products) or to the anti-oxidant hypothesis (beta-carotene, selenium and polyunsaturated fatty acids). From 6 interactions evaluated, the combination of high fiber intake and high intake of fermented milk products was the only one suggesting synergistic protection (age- and-fat-adjusted OR for interaction = 0.48, 95% confidence interval (CI) = 0.21-1.13). In order to estimate the extent to which the above dietary factors together might be related to breast cancer, subjects with a supposedly favorable dietary pattern (low fat intake, high fiber intake, high intake of fermented milk products; high intake of beta-carotene and selenium, low intake of polyunsaturated fatty acids) were compared with subjects with an unfavorable dietary pattern. This resulted in an age-adjusted odds ratio of 0.40 (95% CI = 0.14-1.15), which was largely attributable to the combination of low intake of fat and high intake of fermented milk products and fiber (age-adjusted OR = 0.33, 95% CI = 0.15-0.73). The other factors did not appreciably affect the odds ratio. These analyses show in a quantitative way that a dietary pattern which combines low intake of fat and high intake of fiber and fermented milk products might provide substantial protection against breast cancer. Chemicals/CAS: beta Carotene, 7235-40-7; Calcium, Dietary; Carotenoids, 36-88-4; Dietary Fats, Unsaturated; Selenium, 7782-49-2 Subject Breast cancerCancer riskCase control studyControlled studyFat intakeMajor clinical studyAdultAge FactorsAlcohol Drinkingbeta CaroteneBreast NeoplasmsCalcium, DietaryCarotenoidsDietDietary Fats, UnsaturatedDietary FiberFemaleHumanMiddle AgeNetherlandsRisk FactorsSelenium To reference this document use: http://resolver.tudelft.nl/uuid:4e971196-31da-4fcb-b492-19f7d8d613c0 TNO identifier 231446 ISSN 0020-7136 Source International Journal of Cancer, 47 (5), 649-653 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.