Title
Height, body mass index, and ovarian cancer: A pooled analysis of 12 cohort studies
Author
Schouten, L.J.
Rivera, C.
Hunter, D.J.
Spiegelman, D.
Adami, H.-O.
Arslan, A.
Beeson, W.L.
van den Brandt, P.A.
Buring, J.E.
Folsom, A.R.
Fraser, G.E.
Freudenheim, J.L.
Goldbohm, R.A.
Hankinson, S.E.
Lacey Jr., J.V.
Leitzmann, M.
Lukanova, A.
Marshall, J.R.
Miller, A.B.
Patel, A.V.
Rodriguez, C.
Rohan, T.E.
Ross, J.A.
Wolk, A.
Zhang, S.M.
Smith-Warner, S.A.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
Background: Although many studies have investigated the association between anthropometry and ovarian cancer risk, results have been inconsistent. Methods: The associations of height, body mass index (BMI), and ovarian cancer risk were examined in a pooled analysis of primary data from 12 prospective cohort studies from North America and Europe. The study population consisted of 531,583 women among whom 2,036 epithelial ovarian cancer cases were identified. To summarize associations, study-specific relative risks (RR) were estimated using the Cox proportional hazards model and then combined using a random- effects model. Results: Women with height ≥1.70 m had a pooled multivariate RR of 1.38 [95% confidence interval (95% CI), 1.16-1.65] compared with those with height <1.60 m. For the same comparison, multivariate RRs were 1.79 (95% CI, 1.07-3.00) for premenopausal and 1.25 (95% CI, 1.04-1.49) for postmenopausal ovarian cancer (Pinteraction = 0.14). The multivariate RR for women with a BMI ≥30 kg/m2 was 1.03 (95% CI, 0.86-1.22) compared with women with a BMI from 18.5 to 23 kg/m2. For the same comparison, multivariate RRs were 1.72 (95% CI, 1.02-2.89) for premenopausal and 1.07 (95% CI, 0.87-1.33) for postmenopausal women (Pinteraction = 0.07). There was no statistically significant heterogeneity between studies with respect to height or BMI. BMI in early adulthood was not associated with ovarian cancer risk. Conclusion: Height was associated with an increased ovarian cancer risk, especially in premenopausal women. BMI was not associated with ovarian cancer risk in postmenopausal women but was positively associated with risk in premenopausal women. Copyright © 2008 American Association for Cancer Research.
Subject
adolescent
adult
aged
article
body height
body mass
cancer risk
female
human
major clinical study
ovary cancer
postmenopause
priority journal
proportional hazards model
Body Height
Body Mass Index
Cohort Studies
Female
Humans
Multicenter Studies as Topic
Ovarian Neoplasms
Postmenopause
Premenopause
Proportional Hazards Models
Risk
To reference this document use:
http://resolver.tudelft.nl/uuid:4e7fea47-94b0-402d-a153-4b712879f1b3
DOI
https://doi.org/10.1158/1055-9965.epi-07-2524
TNO identifier
240741
ISSN
1055-9965
Source
Cancer Epidemiology Biomarkers and Prevention, 17 (4), 902-912
Document type
article