Print Email Facebook Twitter Dietary acrylamide intake is not associated with gastrointestinal cancer risk Title Dietary acrylamide intake is not associated with gastrointestinal cancer risk Author Hogervorst, J.G.F. Schouten, L.J. Konings, E.J.M. Goldbohm, R.A. van den Brandt, P.A. TNO Kwaliteit van Leven Publication year 2008 Abstract Acrylamide is a probable human carcinogen that was detected in several heat-treated foods, such as French fries and crisps, in 2002. Prospective studies are needed on acrylamide and human cancer risk. We prospectively investigated the association between acrylamide and gastrointestinal cancer risk. In 1986, 120,852 men and women (aged 55-69 y) were included in the Netherlands Cohort Study on diet and cancer. At baseline, a random subcohort of 5000 participants was selected for a case-cohort approach. Acrylamide intake was assessed with a FFQ at baseline and was based on acrylamide analyses in relevant Dutch foods. After 13.3 y of follow-up, 2190, 563, 349, and 216 cases of colorectal, gastric, pancreatic, and esophageal cancer, respectively, were available for analysis. The daily acrylamide intake of the subcohort was (mean ± SD) 21.7 ± 12.1μg. A 10-μg/d increment of acrylamide intake was associated with multivariable-adjusted Cox proportional hazard rate ratios (HR) (95% CI) of 1.00 (0.96-1.06), 1.02 (0.94-1.10), 1.06 (0.96-1.17), and 0.96 (0.85-1.09) for colorectal, gastric, pancreatic, and esophageal cancer, respectively. For former or never-smokers, the corresponding HR were: 1.03 (0.94-1.12), 1.09 (0.98-1.22), 1.07 (0.93-1.24), and 0.92 (0.76-1.11). There were some significantly increased risks within subgroups stratified by obesity, nonoccupational physical activity, and age, factors that were a priori selected based on their capacity to modify cytochrome P4502E1 activity. Overall, acrylamide intake was not associated with colorectal, gastric, pancreatic, and esophageal cancer risk, but some subgroups deserve further attention. © 2008 American Society for Nutrition. Subject Healthy for LifeHealthHealthy Livingacrylamidecytochrome P450 2E1adultagedarticlecancer riskcolorectal cancerdigestive system cancerdisease associationenzyme activityesophagus cancerfemalefood intakehumanmaleobesitypancreas cancerphysical activityprotein intakesmokingstomach cancerAcrylamideAgedCarcinogensCase-Control StudiesCohort StudiesDietFemaleFood ContaminationGastrointestinal NeoplasmsHumansMaleMiddle AgedOdds RatioProportional Hazards Models To reference this document use: http://resolver.tudelft.nl/uuid:4e770f22-c6fc-4204-a8ca-182b6f38fe82 DOI https://doi.org/10.3945/jn.108.092957 TNO identifier 241090 ISSN 0022-3166 Source Journal of Nutrition, 138 (11), 2229-2236 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.