Title
An amino acid polymorphism in histidine-rich glycoprotein (HRG) explains 59% of the variance in plasma HRG levels
Author
Hennis, B.C.
Boomsma, D.I.
van Boheemen, P.A.
Engesser, L.
Kievit, P.
Dooijewaard, G.
Kluft, C.
TNO Preventie en Gezondheid
Publication year
1995
Abstract
A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual environmental factors of 27%. These results are remarkably similar to the results found in a previous parent-twin study in which a heritability of 69% and an effect of random environment of 31% was found. The overall genetic influence in the present study can be subdivided into an effect of 59% by the HRG phenotype and 11% by residual genetic factors. The influence of the HRG phenotype of 59% can entirely be explained by adding up the effect of the two alleles that make up the phenotype. These results indicate a codominant inheritance pattern of HRG levels in which the genetic influence can almost completely be ascribed to the additive effect of the di-allelic HRG locus whereas only a small part is due to other loci.
Subject
Biology
glycoprotein
histidine
adult
age
article
blood level
controlled study
environmental factor
genetic polymorphism
human
inheritance
major clinical study
maximum likelihood method
normal human
pedigree
priority journal
Alleles
Amino Acids
Analysis of Variance
Blood Proteins
Case-Control Studies
Chromosome Mapping
Glycoproteins
Humans
Likelihood Functions
Molecular Weight
Pedigree
Phenotype
Polymorphism, Genetic
Proteins
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TNO identifier
233073
ISSN
0340-6245
Source
Thrombosis and Haemostasis, 74 (6), 1497-1500
Document type
article