Title
Obese older type 2 diabetes mellitus patients with muscle insulin resistance benefit from an enriched protein drink during combined lifestyle intervention: The probe study
Author
Pasman, W.J.
Memelink, R.G.
den Bosch, J.V.V.
Begieneman, M.P.V.
van den Brink, W.J.
Weijs, P.J.M.
Wopereis, S.
Publication year
2020
Abstract
Background: Recent research showed that subtypes of patients with type 2 diabetes may differ in response to lifestyle interventions based on their organ-specific insulin resistance (IR). (2) Methods: 123 Subjects with type 2 diabetes were randomized into 13-week lifestyle intervention, receiving either an enriched protein drink (protein+) or an isocaloric control drink (control). Before and after the intervention, anthropometrical and physiological data was collected. An oral glucose tolerance test was used to calculate indices representing organ insulin resistance (muscle, liver, and adipose tissue) and β-cell functioning. In 82 study-compliant subjects (per-protocol), we retrospectively examined the intervention effect in patients with muscle IR (MIR, n = 42) and without MIR (no-MIR, n = 40). (3) Results: Only in patients from the MIR subgroup that received protein+ drink, fasting plasma glucose and insulin, whole body, liver and adipose IR, and appendicular skeletal muscle mass improved versus control. Lifestyle intervention improved body weight and fat mass in both subgroups. Furthermore, for the MIR subgroup decreased systolic blood pressure and increased VO2 peak and for the no-MIR subgroup, a decreased 2-h glucose concentration was found. (4) Conclusions: Enriched protein drink during combined lifestyle intervention seems to be especially effective on increasing muscle mass and improving insulin resistance in obese older, type 2 diabetes patients with muscle IR. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Subject
Combined lifestyle intervention
Diabetic subtypes
Diabetes mellitus
Lifestyle
Intervention
Muscle insulin resistance
Oral glucose tolerance test (OGTT)
Protein drink
Weight loss
To reference this document use:
http://resolver.tudelft.nl/uuid:4d518c94-2f59-4ca5-a460-5c5ffeb3f52f
DOI
https://doi.org/10.3390/nu12102979
TNO identifier
881943
Source
Nutrients, 12 (10), 1-16
Article number
2979
Document type
article